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  Domain Name: NBD_sugar-kinase_HSP
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily. This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 67
Total Disease Mutations Found: 53
This domain occurred 26 times on human genes (35 proteins).



  AORTIC ANEURYSM, FAMILIAL THORACIC 6
  ATRIAL SEPTAL DEFECT 5
  BARAITSER-WINTER SYNDROME 1
  BARAITSER-WINTER SYNDROME 1, ATYPICAL
  BARAITSER-WINTER SYNDROME 2
  CARDIOMYOPATHY, DILATED, 1R
  CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 11
  DEAFNESS, AUTOSOMAL DOMINANT 20
  DEAFNESS, AUTOSOMAL DOMINANT, 20 (DFNA20)
  DYSTONIA, JUVENILE-ONSET
  LEFT VENTRICULAR NONCOMPACTION 4, INCLUDED
  MOYAMOYA DISEASE 5, INCLUDED
  MULTISYSTEMIC SMOOTH MUSCLE DYSFUNCTION SYNDROME
  MYOPATHY, ACTIN, CONGENITAL, WITH CORES
  MYOPATHY, ACTIN, CONGENITAL, WITH EXCESS OF THIN MYOFILAMENTS
  MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION
  NEMALINE MYOPATHY 3


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
nucleotide binding site































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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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