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  Domain Name: NDUO42
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 23
Total Disease Mutations Found: 21
This domain occurred 4 times on human genes (9 proteins).



  LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY
  MITOCHONDRIAL DNA DEPLETION SYNDROME 2 (MYOPATHIC TYPE)
  MITOCHONDRIAL DNA DEPLETION SYNDROME 3 (HEPATOCEREBRAL TYPE)


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for NDUO42









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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