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  Domain Name: OST3_OST6
OST3 / OST6 family. The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation.
No pairwise interactions found for the domain OST3_OST6

Total Mutations Found: 1
Total Disease Mutations Found: 1
This domain occurred 3 times on human genes (6 proteins).



  MENTAL RETARDATION, X-LINKED 95


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   Protein ID            Protein Position

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No Conserved Features/Sites Found for OST3_OST6









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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