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  Domain Name: P4Hc
Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.
No pairwise interactions found for the domain P4Hc

Total Mutations Found: 25
Total Disease Mutations Found: 14
This domain occurred 16 times on human genes (28 proteins).



  BRUCK SYNDROME 2
  EHLERS-DANLOS SYNDROME, TYPE VI
  ERYTHROCYTOSIS, FAMILIAL, 3
  MYOPIA, HIGH, WITH CATARACT AND VITREORTINAL DEGENERATION
  OSTEOGENESIS IMPERFECTA, TYPE VIII


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for P4Hc
















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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