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  Domain Name: PH-like
Pleckstrin homology-like domain. The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 64
Total Disease Mutations Found: 20
This domain occurred 162 times on human genes (296 proteins).



  AARSKOG-SCOTT SYNDROME
  BREAST CANCER, SOMATIC
  CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION
  CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2M
  CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B, WITH NEUTROPENIA
  COLORECTAL CANCER, SOMATIC, INCLUDED;;
  COWDEN DISEASE 6
  HYPOINSULINEMIC HYPOGLYCEMIA AND HEMIHYPERTROPHY
  LYMPHOPROLIFERATIVE SYNDROME 1
  MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME,
  MYOPATHY, CENTRONUCLEAR, 1
  OVARIAN CANCER, SOMATIC, INCLUDED;;
  PROTEUS SYNDROME, S
  SOMATIC
  VARIANT OF UNKNOWN SIGNIFICANCE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for PH-like