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  Domain Name: PI3Ka
Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in a variety of fundamental cellular processes and can be divided into three main classes, defined by their substrate specificity and domain architecture.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 8
Total Disease Mutations Found: 7
This domain occurred 9 times on human genes (21 proteins).



  BREAST CANCER, SOMATIC
  COLORECTAL CANCER, SOMATIC
  COLORECTAL CANCER, SOMATIC, INCLUDED
  COLORECTAL CANCER, SOMATIC, INCLUDED;;
  CONGENITAL LIPOMATOUS OVERGROWTH, VASCULAR MALFORMATIONS, AND EPIDERMAL
  COWDEN DISEASE 5
  GASTRIC
  HEPATOCELLULAR CARCINOMA, SOMATIC
  NEVI, SOMATIC
  NEVUS, EPIDERMAL, SOMATIC, INCLUDED
  OVARIAN CANCER, EPITHELIAL, SOMATIC
  OVARIAN CANCER, EPITHELIAL, SOMATIC, INCLUDED;;


Tips:
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 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for PI3Ka













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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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