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  Domain Name: PIN_FEN1_EXO1-like
PIN domains of Flap Endonuclease-1 (FEN1)-like and Exonuclease-1 (EXO1)-like nucleases, structure-specific, divalent-metal-ion dependent, 5' nucleases. PIN (PilT N terminus) domain of Flap Endonuclease-1 (FEN1) and Exonuclease-1 (EXO1)-like nucleases: FEN1, EXO1, Mkt1, Gap endonuclease 1 (GEN1) and Xeroderma pigmentosum complementation group G (XPG) nuclease are members of the structure-specific, 5' nuclease family that catalyzes hydrolysis of DNA duplex-containing nucleic acid structures during DNA replication, repair, and recombination. These nucleases contain a PIN domain with a helical arch/clamp region (I domain) of variable length (approximately 30 to 800 residues) and a H3TH (helix-3-turn-helix) domain, an atypical helix-hairpin-helix-2-like region. Both the H3TH domain (not included here) and the helical arch/clamp region are involved in DNA binding. Most nucleases within this family also have a carboxylate rich active site that is involved in binding essential divalent metal ion cofactors (Mg2+/Mn2+). Some nucleases in this family have C-terminal extensions that act as interaction sites for other proteins.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 54
Total Disease Mutations Found: 13
This domain occurred 3 times on human genes (8 proteins).



  XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP G (XP-G)
  XERODERMA PIGMENTOSUM GROUP G/COCKAYNE SYNDROME
  XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
active site
metal binding site 1
metal binding site 2
putative 5' ssDNA interac
















































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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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