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  Domain Name: PKS_KR
This enzymatic domain is part of bacterial polyketide synthases. It catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.
No pairwise interactions found for the domain PKS_KR

Total Mutations Found: 18
Total Disease Mutations Found: 5
This domain occurred 17 times on human genes (29 proteins).



  17-@BETA-HYDROXYSTEROID DEHYDROGENASE X DEFICIENCY
  CRANIOOSTEOARTHROPATHY
  D-BIFUNCTIONAL PROTEIN DEFICIENCY
  MENTAL RETARDATION, X-LINKED, SYNDROMIC 10


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No Conserved Features/Sites Found for PKS_KR


































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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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