Home News About DMDM Database Statistics Research Publications Contact  

 
Click for a Larger Image
  Domain Name: PLAT
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 44
Total Disease Mutations Found: 25
This domain occurred 19 times on human genes (33 proteins).



  HEPATIC LIPASE DEFICIENCY
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2 (ARCI2)
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3 (ARCI3)
  RECLASSIFIED - VARIANT OF UNKNOWN SIGNIFICANCE


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for PLAT









Weblogos are Copyright (c) 2002 Regents of the University of California




Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258