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  Domain Name: PLAT
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 44
Total Disease Mutations Found: 25
This domain occurred 19 times on human genes (33 proteins).



  HEPATIC LIPASE DEFICIENCY
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2 (ARCI2)
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3 (ARCI3)
  RECLASSIFIED - VARIANT OF UNKNOWN SIGNIFICANCE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for PLAT









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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