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  Domain Name: PLAT
PLAT/LH2 domain. This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.
No pairwise interactions found for the domain PLAT

Total Mutations Found: 41
Total Disease Mutations Found: 25
This domain occurred 18 times on human genes (31 proteins).



  HEPATIC LIPASE DEFICIENCY
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 2 (ARCI2)
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3
  ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 3 (ARCI3)
  RECLASSIFIED - VARIANT OF UNKNOWN SIGNIFICANCE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for PLAT









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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