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  Domain Name: PTEN_C2
C2 domain of PTEN tumour-suppressor protein. This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.
No pairwise interactions found for the domain PTEN_C2

Total Mutations Found: 13
Total Disease Mutations Found: 9
This domain occurred 8 times on human genes (20 proteins).



  BANNAYAN-RILEY-RUVALCABA SYNDROME
  BANNAYAN-RILEY-RUVALCABA SYNDROME, INCLUDED
  COWDEN DISEASE 1
  COWDEN DISEASE 1, INCLUDED;;
  GLIOMA SUSCEPTIBILITY 2
  MACROCEPHALY/AUTISM SYNDROME
  MALIGNANT MELANOMA, SOMATIC
  MENINGIOMA, INCLUDED
  PROTEUS-LIKE SYNDROME, INCLUDED


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for PTEN_C2















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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