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  Domain Name: RAD23_N
Ubiquitin-like domain of RAD23. RAD23 belongs to a family of adaptor molecules having affinity for both the proteasome and ubiquitinylated proteins and thought to shuttle these ubiquitinylated proteins to the proteasome for destruction. RAD23 interacts with ubiquitin through its C-terminal ubiquitin-associated domains (UBA) and with the proteasome through its N-terminal ubiquitin-like domain (UBL).
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 26
Total Disease Mutations Found: 13
This domain occurred 19 times on human genes (32 proteins).



  PARKINSON DISEASE (PARK)
  PARKINSON DISEASE 2 (PARK2)
  PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
hydrophobic patch
charged pocket










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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