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  Domain Name: RB_B
Retinoblastoma-associated protein B domain. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain. The B domain has a cyclin fold.
No pairwise interactions found for the domain RB_B

Total Mutations Found: 4
Total Disease Mutations Found: 4
This domain occurred 3 times on human genes (6 proteins).



  RETINOBLASTOMA
  SMALL CELL CANCER OF THE LUNG, SOMATIC


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for RB_B









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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