Home News About DMDM Database Statistics Research Publications Contact  

 
  Domain Name: RING
Ring finger. E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain; Various RING fingers exhibit binding activity towards E2 ubiquitin-conjugating enzymes (Ubc' s)
No pairwise interactions found for the domain RING

Total Mutations Found: 74
Total Disease Mutations Found: 14
This domain occurred 247 times on human genes (453 proteins).



  BREAST CANCER (BC)
  BREAST-OVARIAN CANCER, FAMILIAL, 1 (BROVCA1)
  BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
  EPILEPSY, PROGRESSIVE MYOCLONIC 2B
  MOYAMOYA DISEASE 2, SUSCEPTIBILITY TO
  NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA
  NOONAN SYNDROME-LIKE DISORDER WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA
  PEROXISOMAL BIOGENESIS DISORDER 3B


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for RING







Weblogos are Copyright (c) 2002 Regents of the University of California




Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258