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  Domain Name: RNAP_A''
A'' subunit of Archaeal RNA Polymerase (RNAP). Archaeal RNA polymerase (RNAP), like bacterial RNAP, is a large multi-subunit complex responsible for the synthesis of all RNAs in the cell. The relative positioning of the RNAP core is highly conserved between archaeal RNAP and the three classes of eukaryotic RNAPs. In archaea, the largest subunit is split into two polypeptides, A' and A'', which are encoded by separate genes in an operon. Sequence alignments reveal that the archaeal A'' subunit corresponds to the C-terminal one-third of the RNAPII largest subunit (Rpb1). In subunit A'', several loops in the jaw domain are shorter. The RNAPII Rpb1 interacts with the second-largest subunit (Rpb2) to form the DNA entry and RNA exit channels in addition to the catalytic center of RNA synthesis.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 3
Total Disease Mutations Found: 1
This domain occurred 3 times on human genes (5 proteins).



  HYPOGONADISM
  LEUKODYSTROPHY, HYPOMYELINATING, 7, WITHOUT OLIGODONTIA OR HYPOGONADOTROPIC


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
Rpb1_C (A") - Rpb1_N (A')
Rpb1_C (A") - Rpb2 (B) in
Rpb1_C (A") - Rpb5 (H) in
Rpb1_C (A") - Rpb6 (K) in
Rpb1_C (A") - Rpb7 (E) in
DNA binding site
cleft
clamp






Feature: Rpb1_C (A") - Rpb6 (K) in.

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Feature: Rpb1_C (A") - Rpb6 (K) in.
Feature: cleft.

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Feature: Rpb1_C (A") - Rpb6 (K) in.
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Feature: Rpb1_C (A") - Rpb2 (B) in.
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Feature: Rpb1_C (A") - Rpb2 (B) in.
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Feature: Rpb1_C (A") - Rpb5 (H) in.
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Feature: DNA binding site.
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Feature: Rpb1_C (A") - Rpb2 (B) in.
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Feature: Rpb1_C (A") - Rpb2 (B) in.
Feature: Rpb1_C (A") - Rpb6 (K) in.
Feature: Rpb1_C (A") - Rpb7 (E) in.

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Feature: Rpb1_C (A") - Rpb7 (E) in.

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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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