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  Domain Name: RT_nLTR_like
RT_nLTR: Non-LTR (long terminal repeat) retrotransposon and non-LTR retrovirus reverse transcriptase (RT). This subfamily contains both non-LTR retrotransposons and non-LTR retrovirus RTs. RTs catalyze the conversion of single-stranded RNA into double-stranded DNA for integration into host chromosomes. RT is a multifunctional enzyme with RNA-directed DNA polymerase, DNA directed DNA polymerase and ribonuclease hybrid (RNase H) activities.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 22
Total Disease Mutations Found: 13
This domain occurred 1 times on human genes (3 proteins).



  BONE MARROW FAILURE, TELOMERE-RELATED, 1
  DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT, 2
  DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE, 4
  PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 1
  PULMONARY FIBROSIS, TELOMERE-RELATED, 1


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
putative active site
putative nucleic acid bin
putative NTP binding site























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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