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  Domain Name: RhoGEF
RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.

Total Mutations Found: 40
Total Disease Mutations Found: 9
This domain occurred 58 times on human genes (114 proteins).



  AARSKOG-SCOTT SYNDROME
  AARSKOG-SCOTT SYNDROME WITH ATTENTION DEFICIT-HYPERACTIVITY DISORDER
  CHARCOT-MARIE-TOOTH DISEASE, TYPE 4H
  NOONAN SYNDROME 4


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for RhoGEF




















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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