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  Domain Name: SAM
Sterile alpha motif. Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.
No pairwise interactions found for the domain SAM

Total Mutations Found: 20
Total Disease Mutations Found: 6
This domain occurred 88 times on human genes (193 proteins).



  CATARACT 6, POSTERIOR POLAR
  MICROCEPHALY 11, PRIMARY, AUTOSOMAL RECESSIVE (1 FAMILY)
  RAPP-HODGKIN SYNDROME
  RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for SAM







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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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