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  Domain Name: SH2
SH2 domain.

Total Mutations Found: 73
Total Disease Mutations Found: 40
This domain occurred 92 times on human genes (202 proteins).



  AUTOINFLAMMATION, ANTIBODY DEFICIENCY, AND IMMUNE DYSREGULATION, PLCG2-ASSOCIATED
  BASAL CELL CARCINOMA, SOMATIC
  GROWTH HORMONE INSENSITIVITY WITH IMMUNODEFICIENCY
  HYPER-IGE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT
  LEOPARD SYNDROME 1 (LEOPARD1)
  LEUKEMIA, JUVENILE MYELOMONOCYTIC (JMML)
  LEUKEMIA, JUVENILE MYELOMONOCYTIC, SOMATIC
  LYMPHOPROLIFERATIVE SYNDROME, X-LINKED, 1
  METACHONDROMATOSIS
  MYCOBACTERIAL AND VIRAL INFECTIONS, SUSCEPTIBILITY TO, AUTOSOMAL RECESSIVE
  NOONAN SYNDROME
  NOONAN SYNDROME 1
  NOONAN SYNDROME 1 (NS1)
  SHORT SYNDROME


Tips:
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 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for SH2







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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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