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  Domain Name: SH3
Src homology 3 domains. Src homology 3 (SH3) domains bind to target proteins through sequences containing proline and hydrophobic amino acids. Pro-containing polypeptides may bind to SH3 domains in 2 different binding orientations.
No pairwise interactions found for the domain SH3

Total Mutations Found: 84
Total Disease Mutations Found: 21
This domain occurred 202 times on human genes (516 proteins).



  CAPILLARY MALFORMATION WITHOUT ARTERIOVENOUS MALFORMATION
  EPILEPSY, GENERALIZED IDIOPATHIC, SUSCEPTIBILITY TO, 9
  EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 8
  EPISODIC ATAXIA, TYPE 5, INCLUDED
  GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME B-POSITIVE,
  MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 11
  MENTAL RETARDATION AND MICROCEPHALY WITH PONTINE AND CEREBELLAR HYPOPLASIA
  MYOPATHY, CENTRONUCLEAR, AUTOSOMAL RECESSIVE
  NATIVE AMERICAN MYOPATHY
  PEROXISOME BIOGENESIS DISORDER 11B
  SHORT SYNDROME (SHORTS)
  TYPE I


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for SH3








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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