Home News About DMDM Database Statistics Research Publications Contact  

 
Click for a Larger Image
  Domain Name: SH3_2
Variant SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.
No pairwise interactions found for the domain SH3_2

Total Mutations Found: 59
Total Disease Mutations Found: 13
This domain occurred 167 times on human genes (419 proteins).



  EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 8
  GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME B-POSITIVE,
  MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 11
  MENTAL RETARDATION AND MICROCEPHALY WITH PONTINE AND CEREBELLAR HYPOPLASIA
  MYOPATHY, CENTRONUCLEAR, AUTOSOMAL RECESSIVE
  NATIVE AMERICAN MYOPATHY
  TYPE I


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for SH3_2








Weblogos are Copyright (c) 2002 Regents of the University of California




Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258