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  Domain Name: SOX-TCF_HMG-box
SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and transcription factor-like proteins, TCF-1, -3, -4, and LEF-1. They appear to bind the minor groove of the A/T C A A A G/C-motif.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 18
Total Disease Mutations Found: 16
This domain occurred 43 times on human genes (91 proteins).



  ACAMPOMELIC CAMPOMELIC DYSPLASIA
  CAMPOMELIC DYSPLASIA
  CAMPOMELIC DYSPLASIA WITH AUTOSOMAL SEX REVERSAL
  HYPOTRICHOSIS-LYMPHEDEMA-TELANGIECTASIA SYNDROME
  MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO
  MICROPHTHALMIA, SYNDROMIC 3
  VARIANT OF UNKNOWN SIGNIFICANCE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
DNA binding site









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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