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  Domain Name: SP_C-Propep
Surfactant protein C, N terminal propeptide. The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. It's main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide.
No pairwise interactions found for the domain SP_C-Propep

Total Mutations Found: 11
Total Disease Mutations Found: 5
This domain occurred 1 times on human genes (4 proteins).



  PULMONARY SURFACTANT METABOLISM DYSFUNCTION 2 (SMDP2)
  SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for SP_C-Propep







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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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