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  Domain Name: Suppressor_APC
Adenomatous polyposis coli tumour suppressor protein. The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
No pairwise interactions found for the domain Suppressor_APC

Total Mutations Found: 2
Total Disease Mutations Found: 2
This domain occurred 4 times on human genes (8 proteins).



  FAMILIAL ADENOMATOUS POLYPOSIS 1, ATTENUATED


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Suppressor_APC







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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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