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  Domain Name: TB
TB domain. This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

Total Mutations Found: 13
Total Disease Mutations Found: 8
This domain occurred 5 times on human genes (13 proteins).



  ACROMICRIC DYSPLASIA, INCLUDED
  CONTRACTURAL ARACHNODACTYLY, CONGENITAL
  ECTOPIA LENTIS 1, ISOLATED, AUTOSOMAL DOMINANT
  GELEOPHYSIC DYSPLASIA 2
  MARFAN SYNDROME, ATYPICAL
  MICROSPHEROPHAKIA AND/OR MEGALOCORNEA, WITH ECTOPIA LENTIS AND WITH
  OR WITHOUT SECONDARY GLAUCOMA
  STIFF SKIN SYNDROME


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for TB






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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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