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  Domain Name: TBOX
T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 30
Total Disease Mutations Found: 24
This domain occurred 15 times on human genes (24 proteins).



  ATRIAL SEPTAL DEFECT 4
  CLEFT PALATE WITH ANKYLOGLOSSIA
  CONOTRUNCAL ANOMALY FACE SYNDROME/VELOCARDIOFACIAL SYNDROME
  HOLT-ORAM SYNDROME
  SMALL PATELLA SYNDROME
  ULNAR-MAMMARY SYNDROME
  VELOCARDIOFACIAL SYNDROME


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
dimerization interface
DNA binding site













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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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