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  Domain Name: TGFB
Transforming growth factor-beta (TGF-beta) family. Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.
No pairwise interactions found for the domain TGFB

Total Mutations Found: 24
Total Disease Mutations Found: 17
This domain occurred 34 times on human genes (57 proteins).



  BRACHYDACTYLY, TYPE A2, INCLUDED
  BRACHYDACTYLY, TYPE C
  COLOBOMA, OCULAR, INCLUDED
  FIBULAR HYPOPLASIA AND COMPLEX BRACHYDACTYLY
  HETEROTAXY, VISCERAL, 5, AUTOSOMAL
  KLIPPEL-FEIL SYNDROME 3, AUTOSOMAL DOMINANT
  LEFT-RIGHT AXIS MALFORMATIONS
  LOEYS-DIETZ SYNDROME, TYPE 4
  MICROPHTHALMIA, ISOLATED 7
  MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 6
  MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 6, INCLUDED
  MULTIPLE SYNOSTOSES SYNDROME 2
  MULTIPLE SYNOSTOSES SYNDROME 2, INCLUDED
  OROFACIAL CLEFT 11
  RIENHOFF SYNDROME (1 FAMILY)
  SYMPHALANGISM, PROXIMAL, 1B
  TELANGIECTASIA, HEREDITARY HEMORRHAGIC, TYPE 5


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for TGFB








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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