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  Domain Name: TGF_beta_GS
Transforming growth factor beta type I GS-motif. This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation. The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain. Point mutations in the GS motif modify the signaling ability of the type I receptor.

Total Mutations Found: 2
Total Disease Mutations Found: 2
This domain occurred 7 times on human genes (13 proteins).



  FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
  LOEYS-DIETZ SYNDROME, TYPE 1A


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for TGF_beta_GS





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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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