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  Domain Name: TNFR
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and organogenesis. TNFRs domains are elongated with generally three tandem repeats of cysteine-rich domains (CRDs). They fit in the grooves between protomers within the ligand trimer. Some TNFRs, such as NGFR and HveA, bind ligands with no structural similarity to TNF and do not bind ligand trimers.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 32
Total Disease Mutations Found: 18
This domain occurred 25 times on human genes (55 proteins).



  ECTODERMAL DYSPLASIA 10A, HYPOHIDROTIC/HAI
  ECTODERMAL DYSPLASIA 10B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL
  IMMUNODEFICIENCY 16 (1 FAMILY)
  IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 3
  LYMPHOPROLIFERATIVE SYNDROME 2
  OSTEOPETROSIS, AUTOSOMAL RECESSIVE 7
  PAGET DISEASE, JUVENILE
  PERIODIC FEVER, FAMILIAL, AUTOSOMAL DOMINANT
  PROSTATE CANCER, PROGRESSION AND METASTASIS OF
  RECESSIVE


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 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
50's loop TNF binding sit
90's loop TNF binding sit
protein binding site
parallel homodimerization
antiparallel homodimeriza











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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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