Home News About DMDM Database Statistics Research Publications Contact  

 
Click for a Larger Image
  Domain Name: TNFR
Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and organogenesis. TNFRs domains are elongated with generally three tandem repeats of cysteine-rich domains (CRDs). They fit in the grooves between protomers within the ligand trimer. Some TNFRs, such as NGFR and HveA, bind ligands with no structural similarity to TNF and do not bind ligand trimers.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 32
Total Disease Mutations Found: 18
This domain occurred 25 times on human genes (55 proteins).



  ECTODERMAL DYSPLASIA 10A, HYPOHIDROTIC/HAI
  ECTODERMAL DYSPLASIA 10B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL
  IMMUNODEFICIENCY 16 (1 FAMILY)
  IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 3
  LYMPHOPROLIFERATIVE SYNDROME 2
  OSTEOPETROSIS, AUTOSOMAL RECESSIVE 7
  PAGET DISEASE, JUVENILE
  PERIODIC FEVER, FAMILIAL, AUTOSOMAL DOMINANT
  PROSTATE CANCER, PROGRESSION AND METASTASIS OF
  RECESSIVE


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
50's loop TNF binding sit
90's loop TNF binding sit
protein binding site
parallel homodimerization
antiparallel homodimeriza











Weblogos are Copyright (c) 2002 Regents of the University of California




Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258