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  Domain Name: TPP_TK
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 5
Total Disease Mutations Found: 5
This domain occurred 4 times on human genes (8 proteins).



  MAPLE SYRUP URINE DISEASE, CLASSIC, TYPE IA
  MAPLE SYRUP URINE DISEASE, INTERMEDIATE, TYPE IA


Tips:
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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
TPP-binding site
dimer interface
















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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