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  Domain Name: Telomere_Pot1
Protection of telomeres protein POT1. POT1 suppresses unwanted DNA repair activities at telomeres by binding the single-stranded G-rich DNA overhangs at human chromosome ends. TPP1, a binding partner of POT1, along with POT1 forms a complex with telomeric DNA that increases the activity and processivity of the human telomerase core enzyme.These proteins serve as a processivity factor for telomerase during telomere extension.
No pairwise interactions found for the domain Telomere_Pot1

Total Mutations Found: 0
Total Disease Mutations Found: 0
This domain occurred 1 times on human genes (4 proteins).




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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Telomere_Pot1









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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