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  Domain Name: VLCAD
Very long chain acyl-CoA dehydrogenase. VLCAD is an acyl-CoA dehydrogenase (ACAD), which is found in the mitochondria of eukaryotes and in some bacteria. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. VLCAD acts as a homodimer.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 68
Total Disease Mutations Found: 57
This domain occurred 11 times on human genes (24 proteins).



  2-@METHYLBUTYRYL-COA DEHYDROGENASE DEFICIENCY
  ACYL-COA DEHYDROGENASE SHORT-CHAIN DEFICIENCY (ACADSD)
  ISOVALERIC ACIDEMIA
  ISOVALERIC ACIDEMIA, TYPE I
  PEROXISOMAL ACYL-COA OXIDASE DEFICIENCY
  SCAD DEFICIENCY
  SCAD DEFICIENCY, MILD
  VLCAD DEFICIENCY


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 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
FAD binding site
substrate binding pocket
catalytic base



















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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