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  Domain Name: class_II_aaRS-like_c
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 21
Total Disease Mutations Found: 16
This domain occurred 15 times on human genes (22 proteins).



  CHARCOT-MARIE-TOOTH DISEASE 2N (CMT2N)
  CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2D
  CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2N
  DEAFNESS, AUTOSOMAL RECESSIVE 89
  HYPERURICEMIA, PULMONARY HYPERTENSION, RENAL FAILURE, AND ALKALOSIS
  HYPOMYELINATION WITH BRAINSTEM AND SPINAL CORD INVOLVEMENT AND LEG
  LACTATE ELEVATION
  LEUKOENCEPHALOPATHY WITH BRAINSTEM AND SPINAL CORD INVOLVEMENT AND
  NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE V
  NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE V, INCLUDED
  SPASTICITY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
active site
dimer interface
motif 1
motif 2
motif 3



























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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