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  Domain Name: gamma_tubulin
Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 79
Total Disease Mutations Found: 54
This domain occurred 19 times on human genes (29 proteins).



  CONGENITAL FIBROSIS OF EXTRAOCULAR MUSCLES 3A (CFEOM3A)
  CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 1
  CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 1 (CDCBM1)
  CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 4
  DYSTONIA 4, TORSION, AUTOSOMAL DOMINANT
  FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 3A, WITH OR WITHOUT EXTRAOCULAR
  INVOLVEMENT
  LEUKODYSTROPHY, HYPOMYELINATING, 6
  LEUKODYSTROPHY, HYPOMYELINATING, 6 (HLD)
  LISSENCEPHALY 3
  LISSENCEPHALY 3 (LIS3)
  MACROTHROMBOCYTOPENIA, AUTOSOMAL DOMINANT, TUBB1-RELATED
  MACROTHROMBOCYTOPENIA, AUTOSOMAL DOMINANT, TUBB1-RELATED (MAD-TUBB1)
  POLYMICROGYRIA, ASYMMETRIC
  POLYMICROGYRIA, SYMMETRIC
  POLYMICROGYRIA, SYMMETRIC OR ASYMMETRIC (PMGYSA)


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
nucleotide binding site





















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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