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  Domain Name: homeodomain
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 109
Total Disease Mutations Found: 80
This domain occurred 177 times on human genes (289 proteins).



  ANIRIDIA
  ANIRIDIA, CEREBELLAR ATAXIA, AND MENTAL RETARDATION
  AXENFELD-RIEGER SYNDROME, TYPE 1
  CLUBFOOT, CONGENITAL, WITH OR WITHOUT DEFICIENCY OF LONG BONES AND/OR
  COLOBOMA OF OPTIC NERVE
  COLOBOMA, OCULAR, INCLUDED
  CONE-ROD DYSTROPHY 2
  CORPUS CALLOSUM, AGENESIS OF, WITH ABNORMAL GENITALIA
  CURRARINO SYNDROME
  DIABETES MELLITUS, INSULIN-DEPENDENT, 20
  EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1
  FACIAL PARESIS, HEREDITARY CONGENITAL, 3
  FRONTONASAL DYSPLASIA 1
  FRONTONASAL DYSPLASIA 2
  HAMAMY SYNDROME
  HAND-FOOT-GENITAL SYNDROME
  HOLOPROSENCEPHALY 2
  HYDRANENCEPHALY WITH ABNORMAL GENITALIA
  LANGER MESOMELIC DYSPLASIA
  LANGER MESOMELIC DYSPLASIA, INCLUDED
  LEBER CONGENITAL AMAUROSIS 7
  LERI-WEILL DYSCHONDROSTEOSIS
  LERI-WEILL DYSCHONDROSTEOSIS, INCLUDED
  LISSENCEPHALY, X-LINKED, 2
  MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3
  MICROPHTHALMIA, ISOLATED 3
  MICROPHTHALMIA, ISOLATED, WITH CATARACT 2
  MICROPHTHALMIA, SYNDROMIC 11
  MICROPHTHALMIA, SYNDROMIC 5
  MIRROR-IMAGE POLYDACTYLY
  NAIL-PATELLA SYNDROME
  NEUROBLASTOMA WITH HIRSCHSPRUNG DISEASE
  NEUROBLASTOMA, SUSCEPTIBILITY TO, 2
  PARIETAL FORAMINA 2
  PITUITARY HORMONE DEFICIENCY, COMBINED, 2
  PITUITARY HORMONE DEFICIENCY, COMBINED, 3
  PITUITARY HORMONE DEFICIENCY, COMBINED, 4
  PREMATURE OVARIAN FAILURE 5
  RECESSIVE (1 FAMILY)
  RENAL CYSTS AND DIABETES SYNDROME
  SPLIT-HAND/FOOT MALFORMATION 1 WITH SENSORINEURAL HEARING LOSS, AUTOSOMAL
  TOOTH AGENESIS, SELECTIVE, 1
  WITKOP SYNDROME


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
specific DNA base contact
DNA binding site










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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