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  Domain Name: recA_like
RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs radA and radB.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 26
Total Disease Mutations Found: 14
This domain occurred 7 times on human genes (18 proteins).



  BREAST CANCER, FAMILIAL
  BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
  BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 4
  FANCONI ANEMIA, COMPLEMENTATION GROUP O
  MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 6
  MIRROR MOVEMENTS 2, SUSCEPTIBILITY TO
  VARIANT OF UNKNOWN SIGNIFICANCE


Tips:
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 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
ATP binding site
Walker A motif
Walker B motif
hexamer interface


















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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