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  Domain Name: wnt
wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.
No pairwise interactions found for the domain wnt

Total Mutations Found: 12
Total Disease Mutations Found: 10
This domain occurred 12 times on human genes (19 proteins).



  FUHRMANN SYNDROME
  ROBINOW SYNDROME, AUTOSOMAL DOMINANT
  TETRAAMELIA, AUTOSOMAL RECESSIVE
  ULNA AND FIBULA, ABSENCE OF, WITH SEVERE LIMB DEFICIENCY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for wnt

























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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