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  Domain Name: zf-C3HC4
Zinc finger, C3HC4 type (RING finger). The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.

Total Mutations Found: 66
Total Disease Mutations Found: 11
This domain occurred 157 times on human genes (260 proteins).



  BREAST CANCER (BC)
  BREAST-OVARIAN CANCER, FAMILIAL, 1 (BROVCA1)
  BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1
  MOYAMOYA DISEASE 2, SUSCEPTIBILITY TO
  NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA
  NOONAN SYNDROME-LIKE DISORDER WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for zf-C3HC4






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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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