Results for the protein: Q6ZN16

Results for the Protein: Q6ZN16

116248533

389840

MAP3K15

NCBI, UniProt

M3K15_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase 15; AltName: Full=Apoptosis signal-regulating kinase 3; AltName: Full=MAPK/ERK kinase kinase 15; Short=MEK kinase 15; Short=MEKK 15

			0 13 0 1 12

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Swiss-Prot Protein: Q6ZN16

Identical to: NP_001001671

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK1	cd05622	4e-05	599	987
STKc_ROCK2	cd05621	1.3e-06	614	986
STKc_ROCK	cd05596	2.5e-05	620	979
STKc_JNK1	cd07875	0.00032	620	987
STKc_PAK2	cd06655	2.4e-19	621	945
STKc_PAK5	cd06658	4.8e-12	622	918
STKc_PAK6	cd06659	7.3e-13	624	926
STKc_JNK3	cd07874	2.7e-05	626	993
PKc_MKK5	cd06619	1.8e-13	627	928
STKc_TAO1	cd06635	1.7e-10	629	937
STKc_PAK	cd06614	5.8e-30	632	923
STKc_p38alpha_MAPK14	cd07877	7e-06	632	953
STKc_JNK	cd07850	5.8e-06	633	977
STKc_myosinIIIB	cd06639	1e-16	634	909
STKc_p38delta_MAPK13	cd07879	0.001	634	995
STKc_p38gamma_MAPK12	cd07880	1.9e-07	634	981
PTKc_EGFR_like	cd05057	1e-07	635	922
STKc_PAK4	cd06657	6.4e-11	635	920
PKc_MKK7	cd06618	5.6e-13	636	927
STKc_PAK_II	cd06648	2.9e-16	636	921
STKc_TAO3	cd06633	1.4e-08	637	947
STKc_p38	cd07851	5.2e-09	637	940
STKc_p38beta_MAPK11	cd07878	2.8e-05	637	988
PTKc_FGFR	cd05053	1.2e-06	638	912
STKc_MAP4K4_6	cd06636	4.7e-23	638	908
STKc_myosinIIIA	cd06638	1.1e-20	638	908
STKc_PAK1	cd06654	7.4e-17	638	928
STKc_JNK2	cd07876	0.00019	638	1021
STKc_TAO	cd06607	4.2e-11	639	947
STKc_TAO2	cd06634	8.5e-12	639	948
STKc_PAK_I	cd06647	1.8e-24	639	926
STKc_PAK3	cd06656	5.7e-17	639	946
PTKc_FGFR1	cd05098	2.2e-06	641	918
STKc_MAP4K5	cd06646	3.5e-25	641	907
STKc_ERK5	cd07855	5e-10	641	937
STKc_CDK9	cd07865	1.2e-12	641	908
STKc_MAP4K3	cd06645	4.5e-25	642	907
PTKc_FGFR4	cd05099	2.4e-07	643	924
PTKc_FGFR3	cd05100	1.8e-05	643	960
PTKc_EGFR	cd05108	2.4e-07	643	959
STKc_MAP4K3_like	cd06613	1.2e-40	643	907
STKc_ASK	cd06624	6.8e-201	643	908
STKc_SLK	cd06643	1.4e-26	643	924
PTKc_FGFR2	cd05101	1.3e-06	644	918
PKc_STE	cd05122	5.2e-117	644	907
STKc_MAPKKK	cd06606	1e-127	644	908
STKc_Nek10	cd08528	7.7e-13	644	905
PTKc_InsR_like	cd05032	2.6e-09	645	910
PTKc_Src_like	cd05034	2e-08	645	907
PTKc_Jak_rpt2	cd05038	5.7e-12	645	912
PTKc_Abl	cd05052	3.3e-08	645	912
PTKc_InsR	cd05061	1.8e-08	645	921
PTKc_IGF-1R	cd05062	9e-08	645	905
PTKc_Lck_Blk	cd05067	9.1e-06	645	911
PTKc_FAK	cd05056	7.7e-10	645	916
PTKc_Frk_like	cd05068	2.1e-09	645	907
PTKc_Yes	cd05069	2.1e-06	645	911
PTKc_Fyn_Yrk	cd05070	3.1e-06	645	911
PTKc_Lyn	cd05072	7.1e-08	645	907
PTKc_Hck	cd05073	9.5e-08	645	907
PTKc_Src	cd05071	1e-06	645	913
PTKc_Csk	cd05082	1.8e-06	645	911
PTKc_Chk	cd05083	1.6e-08	645	910
PTKc_HER2	cd05109	7.2e-06	645	922
PTKc_HER4	cd05110	2.1e-05	645	949
PKc_MKK4	cd06616	5.3e-10	645	931
STKc_ERK1_2_like	cd07849	1.8e-09	645	942
STKc_CDK12	cd07864	5.6e-13	645	908
STKc_CDC2L6	cd07867	4.7e-07	645	908
STKc_CDK8	cd07868	1.7e-06	645	955
STKc_TEY_MAPK_plant	cd07858	4e-09	645	975
PTKc_Musk	cd05050	8.6e-08	646	910
PTKc_EphR_A2	cd05063	2.6e-07	646	908
PTKc_EphR_A10	cd05064	1.8e-05	646	911
PTKc_Ror1	cd05090	0.00022	646	906
PTKc_DDR2	cd05095	0.00015	646	910
PTKc_DDR_like	cd05097	0.00051	646	910
PKc_MEK1	cd06650	1.3e-06	646	943
STKc_CDK7	cd07841	6.9e-16	646	920
PTKc_EphR	cd05033	1.2e-07	647	908
PTKc_EphR_B	cd05065	6.8e-07	647	908
PTKc_Jak1_rpt2	cd05079	4.6e-07	647	911
PTK_HER3	cd05111	8.9e-08	647	921
PTKc_Itk	cd05112	3.1e-10	647	907
PTKc_Btk_Bmx	cd05113	2.1e-09	647	907
PTKc_Tec_Rlk	cd05114	5.8e-10	647	907
PTKc_Tie2	cd05088	1.2e-05	647	926
STKc_STK10_LOK	cd06644	4.6e-28	647	926
STKc_CDK9_like	cd07840	4.6e-17	647	908
PTKc_DDR	cd05051	0.00016	648	910
PKc_MAPKK_Byr1_like	cd06620	1.2e-13	648	920
STKc_TNIK	cd06637	3.6e-24	648	908
STKc_MST3	cd06641	1.4e-21	648	920
STKc_CDK8_like	cd07842	2.4e-13	648	908
STKc_PCTAIRE_like	cd07844	1e-12	648	941
STKc_PFTAIRE1	cd07869	2e-05	648	967
PTKc_Tie1	cd05089	3e-05	649	931
PTKc_TrkA	cd05092	7.2e-07	649	909
PTKc_TrkC	cd05094	0.00078	649	974
PTKc_TrkB	cd05093	9.1e-06	649	920
STKc_phototropin_lik	cd05574	1.6e-07	649	916
STKc_PDK1	cd05581	2e-17	649	908
STKc_MRCK_alpha	cd05623	0.00043	649	979
STKc_NDR1	cd05628	2.2e-05	649	972
STKc_MEKK1	cd06630	2.1e-45	649	909
PKc_MEK2	cd06649	1.6e-06	649	941
STKc_MEKK3_like_1	cd06653	7e-47	649	908
STKc_MAPK4_6	cd07854	1.3e-08	649	947
STKc_PFTAIRE2	cd07870	2.3e-07	649	951
STKc_Nek6_Nek7	cd08224	1.4e-13	649	917
STKc_Nek6	cd08228	1e-17	649	917
PTKc_EphR_A	cd05066	7.5e-06	650	912
STKc_cPKC	cd05587	1e-14	650	965
STKc_DMPK_like	cd05597	4.2e-06	650	978
STKc_MAST	cd05609	3.5e-10	650	964
STKc_PRKX_like	cd05612	1.9e-10	650	947
STKc_cPKC_beta	cd05616	9.6e-09	650	965
STKc_NDR2	cd05627	0.00026	650	1013
STKc_NDR_like_fungal	cd05629	0.00011	650	981
STKc_MRCK_beta	cd05624	0.00019	650	984
STKc_MST3_like	cd06609	1.7e-26	650	922
PKc_MEK	cd06615	1.2e-14	650	919
PKc_MKK3_6	cd06617	2.5e-16	650	924
STKc_MEKK3	cd06651	3.5e-49	650	910
STKc_MAPK	cd07834	1.8e-12	650	934
STKc_CdkB_plant	cd07837	5e-13	650	909
STKc_CDKL1_4	cd07847	3.1e-16	650	908
STKc_NLK	cd07853	2.2e-10	650	989
STKc_Nek3	cd08219	2.5e-24	650	908
PTKc_ALK_LTK	cd05036	1.2e-08	651	909
STKc_ROCK_NDR_like	cd05573	6.7e-11	651	985
STKc_GRK4_like	cd05605	2.8e-09	651	940
STKc_cPKC_alpha	cd05615	1e-10	651	967
STKc_LATS1	cd05625	0.00069	651	982
STKc_GRK4	cd05631	4.9e-06	651	929
STKc_GRK5	cd05632	2.7e-07	651	929
STKc_GRK6	cd05630	1.3e-05	651	929
PKc_MAPKK_plant_like	cd06623	8e-53	651	913
STKc_YSK4	cd06631	3.6e-65	651	908
STKc_MEKK3_like	cd06625	3e-69	651	908
STKc_MEKK2	cd06652	6.4e-42	651	909
STKc_Pho85	cd07836	7.4e-15	651	908
STKc_CDK10	cd07845	1.2e-13	651	923
STKc_CDK6	cd07862	2.9e-07	651	930
STKc_PCTAIRE2	cd07872	7.8e-08	651	933
STKc_PCTAIRE1	cd07873	2.4e-07	651	936
STKc_Nek7	cd08229	2.4e-14	651	917
SPS1	COG0515	4.9e-57	651	1122
PTKc_Csk_like	cd05039	9.8e-07	652	861
STKc_MSK_N	cd05583	2.5e-11	652	923
STKc_MSK1_N	cd05613	4.8e-09	652	923
STKc_MSK2_N	cd05614	1.2e-09	652	959
STKc_MST4	cd06640	4.8e-28	652	925
STKc_STK25-YSK1	cd06642	1.2e-24	652	931
STKc_CDK5	cd07839	1.4e-10	652	908
STKc_CDKL5	cd07848	4e-05	652	937
STKc_CDK1_euk	cd07861	9.5e-13	652	908
STKc_CDK2_3	cd07860	1.5e-15	652	908
STKc_CDK4	cd07863	1.7e-09	652	908
STKc_Nek1	cd08218	6.1e-29	652	908
STKc_Nek8	cd08220	7.3e-30	652	908
STKc_Nek9	cd08221	2e-14	652	908
STKc_MST1_2	cd06612	5.7e-33	653	908
STKc_myosinIII_like	cd06608	2.8e-19	653	908
PKc_MAPKK_PBS2_like	cd06622	3.4e-15	653	965
PKc_MAPKK_Pek1_like	cd06621	1.8e-16	653	921
PTK_Ryk	cd05043	0.00023	654	873
PTK_CCK4	cd05046	0.00036	654	910
PTKc_Tyk2_rpt2	cd05080	1.4e-08	654	913
PTKc_Jak2_Jak3_rpt2	cd05081	8.4e-09	654	909
PTKc_Fes	cd05084	1.4e-09	654	908
PKc_MAPKK	cd06605	9e-20	654	913
STKc_MAPKKK_Byr2_lik	cd06628	3.2e-68	654	908
STKc_CDK1_like	cd07835	1.8e-15	654	908
STKc_MAPK15	cd07852	7.4e-10	654	941
STKc_Sty1_Hog1	cd07856	5.1e-09	654	939
STKc_PCTAIRE3	cd07871	3.3e-09	654	926
STKc_Nek	cd08215	1.9e-43	654	908
STKc_FA2-like	cd08529	7.7e-16	654	908
PTKc_Srm_Brk	cd05148	4.3e-08	655	908
STKc_Yank1	cd05578	7.2e-13	655	908
STKc_RSK_N	cd05582	2.5e-10	655	969
STKc_p70S6K	cd05584	2.5e-15	655	980
STKc_CRIK	cd05601	9.6e-08	655	978
STKc_MEKK4	cd06626	8.5e-61	655	908
STKc_Cdc7_like	cd06627	3.2e-68	655	908
STKc_MOK	cd07831	2.1e-12	655	908
STKc_TDY_MAPK_plant	cd07859	9e-09	655	990
STKc_Nek11	cd08222	3.9e-21	655	908
STKc_Nek4	cd08223	3.7e-20	655	908
PK_STRAD_beta	cd08226	4.8e-05	655	924
PTKc	cd00192	2.4e-16	656	907
PTKc_Ack_like	cd05040	1.9e-11	656	909
PTKc_c-ros	cd05044	5.9e-07	656	905
PTKc_Met_Ron	cd05058	3.2e-06	656	914
PTKc_Zap-70	cd05115	1.2e-08	656	913
PTKc_Syk	cd05116	2e-06	656	908
STKc_PKB	cd05571	1.6e-12	656	981
STKc_SGK	cd05575	1.2e-07	656	968
STKc_PKC	cd05570	5.5e-13	656	954
STKc_aPKC	cd05588	2.3e-08	656	980
STKc_PKN	cd05589	7.7e-10	656	966
STKc_nPKC_eta	cd05590	4.2e-08	656	965
STKc_nPKC_epsilon	cd05591	1.3e-09	656	965
STKc_nPKC_theta_delt	cd05592	1.8e-12	656	968
STKc_PKB_gamma	cd05593	8.3e-09	656	971
STKc_PKB_alpha	cd05594	2.5e-09	656	961
STKc_Sid2p_Dbf2p	cd05600	6.6e-06	656	939
STKc_SGK1	cd05602	6.4e-08	656	980
STKc_SGK2	cd05603	2.2e-09	656	969
STKc_PKB_beta	cd05595	1.2e-07	656	981
STKc_SGK3	cd05604	4.2e-06	656	970
STKc_nPKC_theta	cd05619	1.7e-09	656	966
STKc_nPKC_delta	cd05620	1.2e-05	656	975
PK_STRAD	cd08216	8.9e-10	656	923
PK_STRAD_alpha	cd08227	9.9e-05	656	992
PTKc_Axl_like	cd05035	0.00012	657	912
PTKc_RET	cd05045	5.2e-05	657	913
PTKc_Tie	cd05047	3e-05	657	912
PTKc_Trk	cd05049	4.9e-09	657	905
PTKc_Tyro3	cd05074	0.00094	657	912
PTKc_Fer	cd05085	3.8e-09	657	908
STKc_PKA	cd05580	4.1e-12	657	949
STKc_LATS	cd05598	3.9e-06	657	973
STKc_beta_ARK	cd05606	5.7e-09	657	928
STKc_aPKC_zeta	cd05617	3.2e-08	657	967
STKc_aPKC_iota	cd05618	5.3e-07	657	967
STKc_NDR_like	cd05599	0.00024	657	960
STKc_GRK3	cd05633	4.8e-07	657	924
STKc_OSR1_SPAK	cd06610	2.8e-28	657	908
STKc_MAPKKK_Bck1_lik	cd06629	4.6e-48	657	908
STKc_MEKK1_plant	cd06632	2.2e-91	657	908
STKc_NAK1_like	cd06917	4.7e-20	657	920
STKc_CDK_like	cd07829	6.3e-21	657	908
STKc_CCRK	cd07832	7.7e-15	657	909
STKc_CDKL	cd07833	4.7e-14	657	908
STKc_MAK_like	cd07830	9.5e-18	657	908
STKc_CDKL2_3	cd07846	6.7e-13	657	908
STKc_BUR1	cd07866	4.7e-13	657	907
STKc_Nek2	cd08217	7.5e-18	657	908
STKc_Nek5	cd08225	2.3e-32	657	908
PKc	cd00180	8.7e-75	658	906
PTK_Jak_rpt1	cd05037	1.8e-05	658	907
PTKc_Fes_like	cd05041	1.1e-11	658	910
PTKc_Aatyk	cd05042	9.4e-06	658	905
PTKc_Ror	cd05048	1.1e-05	658	861
PTKc_Tec_like	cd05059	1.9e-10	658	907
PTKc_Syk_like	cd05060	2e-10	658	913
PTK_Jak1_rpt1	cd05077	1.6e-05	658	907
PTK_Jak2_Jak3_rpt1	cd05078	4.5e-06	658	907
PTKc_Aatyk1_Aatyk3	cd05087	0.00022	658	907
STKc_CMGC	cd05118	1.8e-17	658	908
STKc_AGC	cd05123	1.3e-22	658	908
STKc_cGK_PKG	cd05572	4.1e-16	658	915
STKc_GRK	cd05577	2.3e-10	658	924
STKc_MAST_like	cd05579	2.2e-17	658	913
STKc_YPK1_like	cd05585	1.2e-08	658	967
STKc_Sck1_like	cd05586	1.3e-09	658	1015
STKc_GRK7	cd05607	2.4e-07	658	928
STKc_GRK1	cd05608	2.5e-11	658	928
STKc_SLK_like	cd06611	1.2e-16	658	923
STKc_CDK4_6_like	cd07838	3.7e-15	658	908
STKc_MPK1	cd07857	1.7e-09	658	935
STKc_CNK2-like	cd08530	1.8e-14	658	908
STKc_Rim15_like	cd05611	4.5e-06	660	914
STKc_CDC2L1	cd07843	5.4e-12	660	908
Pkinase	pfam00069	2.9e-76	653	908
STYKc	smart00221	9.5e-78	652	908
Pkinase_Tyr	pfam07714	6.4e-18	654	907
TyrKc	smart00219	4.7e-15	657	907
S_TKc	smart00220	3.9e-85	662	908
KIND	smart00750	2.9e-07	732	918

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs5909299	Polymorphism	p.ALA192THR	N/A
Swiss-Prot	VAR_040721	Polymorphism	p.ARG494CYS	N/A
Swiss-Prot	VAR_040723	Polymorphism	p.ARG677GLN	N/A
Swiss-Prot	VAR_040719	Polymorphism	p.ARG255SER	N/A
Swiss-Prot	VAR_040726	Polymorphism	p.ASN1029HIS	N/A
Swiss-Prot	VAR_040718	Polymorphism	p.ASP226HIS	N/A
Swiss-Prot	VAR_040728	Polymorphism	p.GLN1251GLU	N/A
Swiss-Prot	VAR_040724	Polymorphism	p.GLY838SER	N/A
Swiss-Prot	VAR_040717	Polymorphism	p.SER199ASN	N/A
Swiss-Prot	VAR_040720	Polymorphism	p.SER456GLY	N/A
Swiss-Prot	VAR_040722	Polymorphism	p.SER562LEU	N/A
Swiss-Prot	VAR_040725	Polymorphism	p.SER993LEU	N/A
Swiss-Prot	VAR_040727	Polymorphism	p.TRP1247ARG	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258