Results for the protein: NP

Results for the Protein: NP_004433

21396504

2048

EPHB2

NCBI

ephrin type-B receptor 2 isoform 2 precursor [Homo sapiens]

Known Diseases associated with this Protein:
PROSTATE CANCER, PROGRESSION AND METASTASIS OF
PROSTATE CANCER, SUSCEPTIBILITY TO, IN AFRICAN AMERICANS

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Tips:

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RefSeq Protein: NP_004433

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
FN3	cd00063	1.5e-14	325	427
FN3	cd00063	1.9e-17	436	527
PTKc_VEGFR	cd05054	2.1e-19	475	888
PTKc_PDGFR_beta	cd05107	1.7e-09	506	886
PTKc_PDGFR	cd05055	1.4e-17	578	885
PTKc_PDGFR_alpha	cd05105	3.5e-13	578	887
STKc_ROCK2	cd05621	0.001	580	944
PTKc_Kit	cd05104	2.8e-13	581	885
STKc_PAK5	cd06658	2.5e-05	584	908
PTKc_CSF-1R	cd05106	3.5e-18	591	886
STKc_TAO1	cd06635	0.00046	600	908
STKc_myosinIIIA	cd06638	0.00019	601	885
STKc_myosinIIIB	cd06639	0.00012	601	886
STKc_PAK6	cd06659	1.2e-07	601	916
STKc_p38	cd07851	5.8e-07	601	937
STKc_p38beta_MAPK11	cd07878	0.00027	601	959
PTKc_FGFR1	cd05098	8.1e-35	602	892
PTKc_FGFR2	cd05101	5.1e-42	602	892
STKc_PAK4	cd06657	4.6e-05	602	910
STKc_PAK1	cd06654	0.001	602	914
PTKc_EGFR_like	cd05057	5.3e-74	603	895
STKc_PAK	cd06614	2.1e-12	603	898
STKc_PAK_II	cd06648	2.9e-08	603	895
STKc_PAK3	cd06656	0.00052	604	916
STKc_JNK	cd07850	0.00026	604	930
STKc_TAO	cd06607	0.00019	605	908
STKc_TAO2	cd06634	3.4e-05	605	933
PTKc_FGFR4	cd05099	1.2e-39	606	903
PTKc_FGFR3	cd05100	1.9e-26	606	927
STKc_p38alpha_MAPK14	cd07877	0.00014	606	937
PTK_Tyk2_rpt1	cd05076	1.5e-07	607	882
STKc_PAK_I	cd06647	0.00084	607	912
PKc_MKK7	cd06618	3.4e-08	609	929
STKc_CDK9	cd07865	9.4e-06	609	894
STKc_STK10_LOK	cd06644	4.3e-06	610	905
PTKc_HER2	cd05109	1.3e-57	611	895
PTKc_DDR	cd05051	1.2e-49	612	883
PTKc_HER4	cd05110	1.9e-48	612	910
STKc_MAP4K4_6	cd06636	0.00017	612	885
STKc_MAP4K3	cd06645	6.2e-05	612	889
STKc_PCTAIRE2	cd07872	0.00017	612	916
PTKc_TrkA	cd05092	2e-56	613	893
PTKc_TrkC	cd05094	2.3e-31	613	892
STKc_ASK	cd06624	2.3e-08	613	885
STKc_ERK5	cd07855	0.00032	613	938
STKc_Sty1_Hog1	cd07856	2.2e-06	613	933
STKc_PCTAIRE3	cd07871	0.00019	613	904
STKc_p38gamma_MAPK12	cd07880	2.2e-05	613	959
PTKc_VEGFR3	cd05102	4.4e-21	614	888
PTKc_EGFR	cd05108	3.7e-52	614	925
PTK_HER3	cd05111	1.1e-48	614	895
PTKc_VEGFR2	cd05103	1e-16	614	888
PTKc_ALK_LTK	cd05036	4.4e-60	615	883
PTKc_FAK	cd05056	5.5e-89	615	889
STKc_TNIK	cd06637	9.6e-05	615	885
STKc_CDK12	cd07864	6.8e-09	615	906
PTKc_InsR_like	cd05032	3.6e-68	616	883
PTKc_Src_like	cd05034	2.5e-99	616	884
PTKc_Csk_like	cd05039	1.7e-71	616	884
PTK_CCK4	cd05046	3.4e-40	616	883
PTKc_Trk	cd05049	1.4e-69	616	883
PTKc_Ror	cd05048	4.6e-63	616	884
PTKc_Abl	cd05052	2.2e-84	616	885
PTKc_FGFR	cd05053	3.2e-42	616	886
PTKc_Musk	cd05050	3.1e-70	616	883
PTKc_IGF-1R	cd05062	5.3e-48	616	883
PTKc_EphR_A2	cd05063	8.9e-186	616	885
PTKc_EphR_A10	cd05064	7.3e-151	616	885
PTKc_Lck_Blk	cd05067	2.6e-79	616	884
PTKc_Frk_like	cd05068	8.4e-99	616	884
PTKc_Yes	cd05069	3.2e-76	616	884
PTKc_Fyn_Yrk	cd05070	1.1e-78	616	884
PTKc_Src	cd05071	8.2e-77	616	886
PTKc_Lyn	cd05072	2.6e-77	616	884
PTKc_Hck	cd05073	6.4e-79	616	884
PTKc_InsR	cd05061	2.1e-49	616	896
PTKc_Csk	cd05082	8.3e-59	616	884
PTKc_Ror2	cd05091	1.9e-58	616	884
PTKc_Ror1	cd05090	2.8e-62	616	884
PTKc_TrkB	cd05093	1.6e-50	616	892
PTKc_DDR2	cd05095	5.1e-52	616	883
PTKc_DDR1	cd05096	5.5e-42	616	883
PTKc_DDR_like	cd05097	1e-54	616	883
PKc_MAPKK_Byr1_like	cd06620	1.9e-08	616	895
STKc_MST3	cd06641	1.4e-07	616	892
STKc_STK25-YSK1	cd06642	5.9e-08	616	892
STKc_MST4	cd06640	1.3e-08	616	892
STKc_TEY_MAPK_plant	cd07858	3.8e-07	616	968
PTKc_EphR	cd05033	1.2e-233	617	885
PTK_Ryk	cd05043	7.7e-24	617	885
PTKc_Tec_like	cd05059	2.2e-75	617	882
PTKc_EphR_A	cd05066	1.2e-210	617	885
PTKc_EphR_B	cd05065	9.6e-231	617	885
PTKc_Jak1_rpt2	cd05079	8.1e-42	617	885
PTKc_Chk	cd05083	5e-68	617	884
PTKc_Tie2	cd05088	5.2e-44	617	903
PTKc_Btk_Bmx	cd05113	9.2e-77	617	882
PTKc_Tec_Rlk	cd05114	9e-78	617	882
PTKc_Itk	cd05112	1.2e-77	617	882
PKc_MAPKK_plant_like	cd06623	5.1e-13	617	890
STKc_ERK1_2_like	cd07849	2.7e-07	617	936
STKc_MAPK15	cd07852	0.00042	617	917
STKc_MAPK4_6	cd07854	0.00011	617	972
STKc_PFTAIRE2	cd07870	0.00056	617	914
STKc_MAPKKK	cd06606	1.5e-18	618	877
STKc_PCTAIRE_like	cd07844	8.9e-06	618	914
STKc_BUR1	cd07866	3e-07	618	874
STKc_phototropin_lik	cd05574	4.4e-07	619	895
STKc_SLK_like	cd06611	1.3e-07	619	900
PKc_MKK3_6	cd06617	5.9e-07	619	903
STKc_Nek6_Nek7	cd08224	1.2e-08	619	886
STKc_Nek6	cd08228	3.1e-07	619	886
STKc_Nek7	cd08229	5.7e-10	619	886
STKc_PKA	cd05580	8.6e-07	620	919
STKc_ROCK_NDR_like	cd05573	0.00081	620	911
STKc_PRKX_like	cd05612	2.6e-07	620	920
STKc_MAST	cd05609	0.00026	620	944
STKc_MRCK_alpha	cd05623	0.00033	620	947
STKc_MRCK_beta	cd05624	0.00095	620	951
STKc_OSR1_SPAK	cd06610	1.5e-10	620	874
STKc_MST3_like	cd06609	9.2e-11	620	892
PKc_MEK	cd06615	2e-06	620	927
PKc_MKK5	cd06619	3.5e-05	620	909
PKc_MAPKK_PBS2_like	cd06622	1.9e-07	620	926
STKc_SLK	cd06643	2.3e-06	620	897
STKc_MEKK3_like_1	cd06653	3.5e-05	620	883
STKc_NAK1_like	cd06917	2.5e-07	620	902
STKc_Pho85	cd07836	1.4e-05	620	906
STKc_CDK5	cd07839	3.8e-05	620	902
STKc_CDK10	cd07845	1.4e-06	620	914
STKc_CDK2_3	cd07860	0.00026	620	914
STKc_CDK1_euk	cd07861	0.00011	620	928
STKc_Nek1	cd08218	2e-06	620	886
SPS1	COG0515	4.1e-25	620	984
PTKc_RET	cd05045	5.3e-49	621	888
PKc_STE	cd05122	6.9e-15	621	874
STKc_GRK4_like	cd05605	6.7e-06	621	913
STKc_MSK1_N	cd05613	0.00084	621	899
STKc_cPKC_alpha	cd05615	0.00018	621	937
STKc_GRK4	cd05631	0.0005	621	906
STKc_GRK5	cd05632	0.00028	621	913
STKc_MEKK3	cd06651	4.1e-06	621	877
STKc_CDK1_like	cd07835	4.7e-05	621	914
STKc_CDC2L1	cd07843	4.3e-06	621	891
STKc_NLK	cd07853	5.3e-06	621	967
STKc_TDY_MAPK_plant	cd07859	1.6e-07	621	959
STKc_Nek4	cd08223	4.9e-07	621	885
STKc_Nek5	cd08225	4.2e-06	621	881
PTKc_Axl_like	cd05035	2.5e-58	622	885
PTKc_Tyro3	cd05074	8.5e-53	622	885
PTKc_Axl	cd05075	2.8e-48	622	885
PTKc_Tyk2_rpt2	cd05080	2.2e-19	622	886
PTKc_Tie1	cd05089	1.6e-46	622	902
PTKc_Jak2_Jak3_rpt2	cd05081	3.4e-38	622	885
STKc_MSK_N	cd05583	0.00024	622	896
STKc_cPKC	cd05587	3.4e-05	622	950
STKc_PKN	cd05589	5.3e-06	622	946
STKc_cPKC_beta	cd05616	0.001	622	942
STKc_MSK2_N	cd05614	0.00066	622	948
PKc_MAPKK	cd06605	2.6e-10	622	879
STKc_myosinIII_like	cd06608	1.1e-07	622	879
STKc_MAPKKK_Bck1_lik	cd06629	2.3e-11	622	875
STKc_CDK9_like	cd07840	4.9e-10	622	901
STKc_Nek3	cd08219	2.4e-09	622	883
PTKc_Jak_rpt2	cd05038	2.9e-62	623	885
STKc_CMGC	cd05118	1.2e-09	623	874
PTKc_Srm_Brk	cd05148	3.9e-78	623	884
STKc_Yank1	cd05578	9.5e-08	623	890
STKc_PDK1	cd05581	1e-07	623	877
STKc_CRIK	cd05601	4.6e-05	623	944
STKc_MST1_2	cd06612	1.5e-11	623	872
STKc_MAP4K3_like	cd06613	7.8e-11	623	882
STKc_MEKK3_like	cd06625	2.3e-09	623	883
STKc_Cdc7_like	cd06627	7.4e-18	623	874
STKc_CDK_like	cd07829	3.2e-10	623	891
STKc_MAK_like	cd07830	1.9e-08	623	874
STKc_MOK	cd07831	0.00043	623	874
STKc_CCRK	cd07832	3.6e-08	623	874
STKc_MAPK	cd07834	6.6e-09	623	933
STKc_CdkB_plant	cd07837	0.0008	623	907
STKc_CDK7	cd07841	3.8e-07	623	878
STKc_CDKL2_3	cd07846	1.7e-05	623	880
STKc_CDKL1_4	cd07847	1.7e-05	623	928
STKc_MPK1	cd07857	1.1e-05	623	954
STKc_CDK4	cd07863	0.00016	623	906
STKc_CDKL	cd07833	0.00096	623	881
STKc_Nek2	cd08217	1.5e-07	623	885
PK_STRAD	cd08216	2.8e-05	623	887
STKc_Nek8	cd08220	2.3e-06	623	885
STKc_Nek	cd08215	9.5e-16	623	884
STKc_CNK2-like	cd08530	1.4e-05	623	881
STKc_Nek10	cd08528	1.8e-05	623	883
STKc_Nek11	cd08222	3.2e-08	624	885
STKc_FA2-like	cd08529	2.7e-08	624	891
STKc_RSK_N	cd05582	7.8e-06	625	946
STKc_p70S6K	cd05584	0.00013	625	948
PKc_MKK4	cd06616	2.4e-06	625	905
PKc_MAPKK_Pek1_like	cd06621	4.3e-07	625	898
STKc_MEKK4	cd06626	6.4e-07	625	875
STKc_CDK4_6_like	cd07838	0.0006	625	864
PTKc	cd00192	1.8e-133	626	882
PTK_Jak_rpt1	cd05037	6e-11	626	882
PTKc_Ack_like	cd05040	2.3e-75	626	883
PTKc_Fes_like	cd05041	1.3e-91	626	883
PTKc_Aatyk	cd05042	1.2e-15	626	883
PTKc_c-ros	cd05044	1.7e-66	626	883
PTKc_Tie	cd05047	2.2e-51	626	886
PTKc_Met_Ron	cd05058	1e-66	626	887
PTKc_Syk_like	cd05060	2.3e-88	626	886
PTK_Jak1_rpt1	cd05077	2.6e-11	626	882
PTK_Jak2_Jak3_rpt1	cd05078	1.1e-11	626	882
PTKc_Fes	cd05084	1.6e-74	626	883
PTKc_Fer	cd05085	6.3e-76	626	883
PTKc_Aatyk2	cd05086	7e-22	626	883
PTKc_Aatyk1_Aatyk3	cd05087	3.3e-21	626	883
PTKc_Syk	cd05116	1.6e-63	626	886
STKc_PKC	cd05570	2.3e-06	626	919
STKc_PKB	cd05571	2.5e-06	626	959
STKc_SGK	cd05575	2.6e-05	626	941
STKc_nPKC_eta	cd05590	0.00016	626	947
STKc_nPKC_epsilon	cd05591	1e-05	626	947
STKc_nPKC_theta_delt	cd05592	1.1e-05	626	948
STKc_PKB_gamma	cd05593	0.00075	626	957
STKc_PKB_alpha	cd05594	0.00049	626	952
STKc_PKB_beta	cd05595	0.00094	626	948
STKc_aPKC	cd05588	0.00098	626	947
STKc_SGK1	cd05602	3e-05	626	948
STKc_SGK2	cd05603	6.6e-06	626	947
STKc_SGK3	cd05604	0.001	626	964
STKc_NDR_like	cd05599	0.00036	626	944
STKc_nPKC_theta	cd05619	2.3e-05	626	948
STKc_MAPKKK_Byr2_lik	cd06628	8.7e-14	626	883
STKc_MEKK1	cd06630	1.6e-07	626	880
STKc_YSK4	cd06631	1.3e-08	626	881
STKc_MEKK1_plant	cd06632	2.7e-10	626	878
STKc_Nek9	cd08221	6.4e-09	627	883
PKc	cd00180	2.2e-61	628	881
PTKc_Zap-70	cd05115	4.5e-76	628	886
STKc_AGC	cd05123	1.6e-08	628	876
STKc_cGK_PKG	cd05572	1.9e-05	628	866
STKc_GRK	cd05577	0.00031	628	912
STKc_MAST_like	cd05579	3e-07	628	880
STKc_YPK1_like	cd05585	4.7e-05	628	940
STKc_GRK7	cd05607	0.00038	628	892
STKc_GRK1	cd05608	0.00018	628	912
	cd00166	1.9e-22	913	976
Ephrin_lbd	pfam01404	2e-131	20	197
fn3	pfam00041	2.3e-19	326	421
fn3	pfam00041	1.3e-20	437	520
Pkinase	pfam00069	1.9e-43	622	881
SAM_1	pfam00536	7.5e-31	912	976
EPH_lbd	smart00615	4.9e-124	20	196
GCC2_GCC3	pfam07699	8.4e-05	259	303
FN3	smart00060	5.6e-09	325	417
FN3	smart00060	1.4e-14	436	517
Pkinase_Tyr	pfam07714	5.7e-149	622	881
TyrKc	smart00219	2.4e-145	622	881
STYKc	smart00221	7.5e-59	622	923
S_TKc	smart00220	8.1e-49	632	885
KIND	smart00750	0.00033	706	891
SAM_2	pfam07647	9.2e-24	911	976
SAM	smart00454	1.5e-25	911	978

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	600997.0002	Disease	p.ALA279SER	PROSTATE CANCER, PROGRESSION AND METASTASIS OF
OMIM	600997.0003	Disease	p.ASP679ASN	PROSTATE CANCER, PROGRESSION AND METASTASIS OF
OMIM	600997.0001	Disease	p.GLN723TER	PROSTATE CANCER, PROGRESSION AND METASTASIS OF
OMIM	600997.0004	Disease	p.LYS1019TER	PROSTATE CANCER, SUSCEPTIBILITY TO, IN AFRICAN AMERICANS

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258