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Results for the Protein: P23458
215274013

JAK1_HUMAN RecName: Full=Tyrosine-protein kinase JAK1; AltName: Full=Janus kinase 1; Short=JAK-1
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

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Default View:

B41 - smart00295
SH2 - smart00252
SH2 - cd00173
PTKc_TrkA - cd05092
PTKc_TrkB - cd05093
PTKc_DDR_like - cd05097
PTKc_Hck - cd05073
PTKc_EphR_A2 - cd05063
PTKc_Csk - cd05082
PTKc_Lyn - cd05072
PTKc_FAK - cd05056
PTKc_Abl - cd05052
PTKc_Frk_like - cd05068
PTKc_Lck_Blk - cd05067
PTKc_Yes - cd05069
PTKc_Fyn_Yrk - cd05070
PTKc_Src - cd05071
PTKc_Tec_Rlk - cd05114
PTKc_Btk_Bmx - cd05113
PTKc_Jak1_rpt2 - cd05079
PTKc_Itk - cd05112
PTKc_EphR_B - cd05065
PTKc_EphR_A - cd05066
PTKc_EphR_A10 - cd05064
PKc_MKK3_6 - cd06617
SPS1 - COG0515
PTKc_Chk - cd05083
STYKc - smart00221
TyrKc - smart00219
Pkinase_Tyr - pfam07714
Pkinase - pfam00069
PTKc_Tyro3 - cd05074
STKc_PKB - cd05571
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc_Met_Ron - cd05058
PTK_Jak_rpt1 - cd05037
PTKc - cd00192
PTK_Tyk2_rpt1 - cd05076
PTK_Jak1_rpt1 - cd05077
PTKc_Fer - cd05085
PTKc_Fes - cd05084
PKc - cd00180
PTKc_Zap-70 - cd05115
PTKc_Syk - cd05116
S_TKc - smart00220
PTKc_PDGFR_alpha - cd05105
PTKc_PDGFR_beta - cd05107
PTKc_VEGFR - cd05054
PTKc_CSF-1R - cd05106
STKc_myosinIIIB - cd06639
STKc_myosinIIIA - cd06638
STKc_PAK - cd06614
PTKc_Kit - cd05104
STKc_PAK3 - cd06656
STKc_TAO - cd06607
STKc_PAK_I - cd06647
PKc_MKK7 - cd06618
PTKc_PDGFR - cd05055
STKc_PAK6 - cd06659
STKc_PAK4 - cd06657
PTKc_FGFR1 - cd05098
STKc_PAK5 - cd06658
STKc_TAO1 - cd06635
STKc_PAK_II - cd06648
STKc_STK10_LOK - cd06644
PTKc_FGFR2 - cd05101
STKc_MAP4K4_6 - cd06636
STKc_TAO2 - cd06634
PTKc_EGFR_like - cd05057
STKc_p38 - cd07851
PTKc_FGFR - cd05053
PTKc_FGFR3 - cd05100
PTKc_FGFR4 - cd05099
STKc_CDK10 - cd07845
STKc_MAP4K5 - cd06646
STKc_TNIK - cd06637
STKc_CDK9 - cd07865
STKc_Sty1_Hog1 - cd07856
STKc_BUR1 - cd07866
STKc_SLK_like - cd06611
STKc_MST3 - cd06641
STKc_MST4 - cd06640
STKc_STK25-YSK1 - cd06642
STKc_ASK - cd06624
STKc_MEKK2 - cd06652
PTKc_Tie2 - cd05088
STKc_MAPK4_6 - cd07854
STKc_ERK1_2_like - cd07849
PKc_MAPKK_plant_like - cd06623
PTKc_DDR - cd05051
PTKc_ALK_LTK - cd05036
STKc_TEY_MAPK_plant - cd07858
PTKc_VEGFR2 - cd05103
STKc_Yank1 - cd05578
PTKc_VEGFR3 - cd05102
PTKc_DDR1 - cd05096
STKc_SLK - cd06643
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE1 - cd07873
PTKc_DDR2 - cd05095
STKc_PFTAIRE2 - cd07870
STKc_ERK5 - cd07855
STKc_PCTAIRE_like - cd07844
STKc_MAP4K3 - cd06645
PTKc_InsR - cd05061
PTKc_TrkC - cd05094
PTK_CCK4 - cd05046
PTKc_Ror - cd05048
PTKc_Trk - cd05049
PTKc_Musk - cd05050
PTKc_IGF-1R - cd05062
PTKc_Ror1 - cd05090
PTKc_Ror2 - cd05091
STKc_MST1_2 - cd06612
STKc_MAP4K3_like - cd06613
PKc_MKK4 - cd06616
STKc_PCTAIRE3 - cd07871
STKc_CDK12 - cd07864
STKc_MAPK15 - cd07852
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Jak_rpt2 - cd05038
PTKc_Src_like - cd05034
PTKc_Tec_like - cd05059
PTKc_EphR - cd05033
PTKc_InsR_like - cd05032
PTKc_Tyk2_rpt2 - cd05080
PTKc_HER4 - cd05110
PTK_HER3 - cd05111
PTKc_EGFR - cd05108
PTKc_HER2 - cd05109
STKc_CDKL5 - cd07848
STKc_MEKK3_like_1 - cd06653
STKc_ROCK_NDR_like - cd05573
PTKc_RET - cd05045
PKc_MAPKK_Pek1_like - cd06621
STKc_Nek6_Nek7 - cd08224
STKc_CDKL1_4 - cd07847
STKc_CDC2L1 - cd07843
STKc_CNK2-like - cd08530
STKc_CDK6 - cd07862
STKc_Nek11 - cd08222
STKc_Cdc7_like - cd06627
STKc_MST3_like - cd06609
STKc_NAK1_like - cd06917
STKc_CDK7 - cd07841
PKc_MEK - cd06615
STKc_PRKX_like - cd05612
STKc_phototropin_lik - cd05574
STKc_MPK1 - cd07857
STKc_PKA - cd05580
STKc_CDK1_euk - cd07861
STKc_Nek - cd08215
STKc_YSK4 - cd06631
STKc_MAPKKK - cd06606
STKc_GRK4_like - cd05605
PKc_STE - cd05122
STKc_CDK8_like - cd07842
STKc_MAPK - cd07834
STKc_CDC2L6 - cd07867
STKc_CDK2_3 - cd07860
STKc_CDK4 - cd07863
STKc_Nek3 - cd08219
STKc_Nek5 - cd08225
STKc_Nek7 - cd08229
STKc_Nek6 - cd08228
STKc_CDK9_like - cd07840
STKc_Nek1 - cd08218
STKc_MSK1_N - cd05613
STKc_PKN - cd05589
STKc_MSK_N - cd05583
PKc_MAPKK - cd06605
PKc_MAPKK_Byr1_like - cd06620
PKc_MAPKK_PBS2_like - cd06622
STKc_MEKK3 - cd06651
PTKc_Axl - cd05075
STKc_MOK - cd07831
STKc_CMGC - cd05118
STKc_CDK1_like - cd07835
STKc_Pho85 - cd07836
STKc_CDK4_6_like - cd07838
STKc_MAK_like - cd07830
STKc_CDK_like - cd07829
PTKc_Axl_like - cd05035
STKc_Nek9 - cd08221
STKc_CDKL2_3 - cd07846
STKc_MEKK3_like - cd06625
STKc_MAPKKK_Byr2_lik - cd06628
STKc_OSR1_SPAK - cd06610
STKc_PDK1 - cd05581
PTK_Ryk - cd05043
STKc_CCRK - cd07832
STKc_CDKL - cd07833
STKc_Nek2 - cd08217
PK_STRAD - cd08216
STKc_CDK5 - cd07839
STKc_CdkB_plant - cd07837
STKc_Nek8 - cd08220
PTKc_Tie1 - cd05089
STKc_MEKK4 - cd06626
PTKc_Srm_Brk - cd05148
PTKc_Csk_like - cd05039
STKc_FA2-like - cd08529
STKc_RSK_N - cd05582
STKc_Nek10 - cd08528
STKc_Nek4 - cd08223
STKc_myosinIII_like - cd06608
STKc_nPKC_theta - cd05619
PTKc_c-ros - cd05044
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_Aatyk2 - cd05086
PTKc_Ack_like - cd05040
STKc_PKC - cd05570
STKc_PKB_alpha - cd05594
PTKc_Syk_like - cd05060
PTKc_Fes_like - cd05041
PTKc_Aatyk - cd05042
PTKc_Tie - cd05047
STKc_MEKK1_plant - cd06632
STKc_AGC - cd05123
STKc_cGK_PKG - cd05572
STKc_MAST_like - cd05579
STKc_GRK - cd05577
STKc_GRK1 - cd05608
STKc_MAPKKK_Bck1_lik - cd06629
STKc_MEKK1 - cd06630


Swiss-Prot Protein: P23458
Identical to: NP_002218
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
PTKc_Ablcd050521.2e-12577849
PTKc_FAKcd050565.5e-18577853
PTKc_Lck_Blkcd050671.7e-06577845
PTKc_Frk_likecd050689.3e-18577848
PTKc_Yescd050692.3e-08577848
PTKc_Fyn_Yrkcd050702.2e-07577845
PTKc_Srccd050711.8e-07577847
PTKc_Lyncd050724.4e-08577848
PTKc_Hckcd050734.7e-09577845
PTKc_Cskcd050821e-08577848
PTKc_TrkAcd050921.6e-08577851
PTKc_TrkBcd050932.1e-08577857
PTKc_EphR_A2cd050639.4e-08577849
PTKc_DDR_likecd050974e-07577847
PTKc_Jak1_rpt2cd050792.3e-05578849
PTKc_Itkcd051123.9e-10578846
PTKc_Btk_Bmxcd051131.3e-09578846
PTKc_Tec_Rlkcd051142.2e-12578846
PTKc_EphR_A10cd050642.3e-08579849
PTKc_EphR_Bcd050651.3e-08579849
PTKc_EphR_Acd050661.8e-07579849
PKc_MKK3_6cd066177.1e-07581864
SPS1COG05153.6e-155811024
PTKc_Tyro3cd050741e-06583849
PTKc_Chkcd050831.2e-09583848
PTKccd001928.6e-36587846
PTK_Jak_rpt1cd050373.8e-152587846
PTKc_Met_Roncd050583.9e-07587851
PTK_Tyk2_rpt1cd050765.9e-138587846
PTK_Jak1_rpt1cd050771e-217587846
PTK_Jak2_Jak3_rpt1cd050782.2e-125587846
PTKc_Fescd050849.4e-14587847
PTKc_Fercd050858.9e-13587847
STKc_PKBcd055710.00019587910
PKccd001808.4e-29589845
PTKc_Zap-70cd051156.3e-12595850
PTKc_Sykcd051161.3e-08595850
PTKc_PDGFR_alphacd051053.1e-117491154
PTKc_PDGFR_betacd051075.9e-087551154
PTKc_VEGFRcd050541.4e-097581154
PTKc_CSF-1Rcd051063.4e-108351154
STKc_myosinIIIBcd066396.5e-058451154
STKc_myosinIIIAcd066380.000248481151
STKc_PAKcd066141.8e-128491153
PTKc_Kitcd051041.5e-118501153
STKc_TAOcd066070.000188521154
STKc_PAK3cd066560.000888521154
PKc_MKK7cd066183.6e-058541148
STKc_PAK_Icd066470.000538541154
PTKc_PDGFRcd050553e-158551153
STKc_PAK6cd066599.2e-068551151
PTKc_FGFR1cd050981.1e-338561154
STKc_PAK4cd066570.000948561152
STKc_PAK5cd066580.000338561132
STKc_TAO1cd066350.000918571154
STKc_PAK_IIcd066482e-068581146
STKc_STK10_LOKcd066441.5e-068591153
PTKc_FGFR2cd051015.6e-328601154
STKc_MAP4K4_6cd066360.000438601133
PTKc_EGFR_likecd050571.9e-488621154
STKc_TAO2cd066347e-058621144
STKc_p38cd078517.4e-058621136
PTKc_FGFRcd050534.5e-348631154
PTKc_FGFR4cd050995.4e-368631154
PTKc_FGFR3cd051008.3e-198631154
STKc_CDK10cd078454.6e-098631121
PTKc_EphR_A2cd050635.8e-388641153
STKc_MAP4K5cd066462.1e-058641125
STKc_TNIKcd066372.7e-058641133
STKc_CDK9cd078651.7e-078641150
STKc_SLK_likecd066117.1e-098651148
STKc_Sty1_Hog1cd078561.8e-058651149
STKc_BUR1cd078662.1e-088651142
STKc_ASKcd066241.7e-098661153
STKc_MST4cd066403.2e-088661153
STKc_MST3cd066412.2e-078661153
STKc_STK25-YSK1cd066427.9e-098661153
STKc_MEKK2cd066521.5e-098671134
PTKc_ALK_LTKcd050361.8e-288681151
PTKc_DDRcd050513.1e-218681147
PTKc_FAKcd050561.4e-558681154
PTKc_Tie2cd050885.1e-208681154
PKc_MAPKK_plant_likecd066231.4e-128681151
STKc_ERK1_2_likecd078495.1e-068681154
STKc_MAPK4_6cd078544.2e-058681150
STKc_TEY_MAPK_plantcd078580.000148681154
PTKc_Rorcd050482.3e-348691152
PTKc_Trkcd050491e-408691151
PTKc_Muskcd050502.3e-408691151
PTKc_Ablcd050521.3e-508691153
PTK_CCK4cd050466.4e-328691151
PTKc_InsRcd050612.1e-198691154
PTKc_IGF-1Rcd050621.8e-278691151
PTKc_EphR_A10cd050649.5e-328691153
PTKc_Lck_Blkcd050672.4e-478691149
PTKc_Frk_likecd050682.2e-658691152
PTKc_Yescd050696.1e-328691149
PTKc_Fyn_Yrkcd050705.2e-338691152
PTKc_Srccd050713.1e-338691154
PTKc_Lyncd050727.9e-428691149
PTKc_Hckcd050731.8e-428691149
PTKc_Cskcd050823.8e-428691152
PTKc_Ror1cd050902.1e-298691152
PTKc_Ror2cd050913.5e-218691152
PTKc_TrkAcd050923.6e-428691151
PTKc_TrkBcd050931.1e-358691154
PTKc_TrkCcd050941.5e-268691154
PTKc_DDR2cd050957.2e-328691151
PTKc_DDR_likecd050979.5e-348691151
PTKc_DDR1cd050966e-268691151
PTKc_VEGFR3cd051028.5e-128691154
PTKc_VEGFR2cd051037.9e-148691154
STKc_Yank1cd055781.1e-068691128
STKc_SLKcd066431.2e-068691151
STKc_MAP4K3cd066454.2e-058691149
STKc_PCTAIRE_likecd078441e-078691151
STKc_ERK5cd078550.000428691154
STKc_PFTAIRE2cd078700.000128691150
STKc_PCTAIRE2cd078721.4e-058691154
STKc_PCTAIRE1cd078731.1e-058691154
PTKc_InsR_likecd050321.1e-388701151
PTKc_Src_likecd050343.9e-488701152
PTKc_Jak_rpt2cd050383.7e-2128701153
PTKc_Tec_likecd050594.3e-248701150
PTKc_EphRcd050337.9e-378701153
PTKc_EphR_Bcd050651.3e-348701153
PTKc_EphR_Acd050666.3e-418701153
PTKc_Tyk2_rpt2cd050805.2e-1628701154
PTKc_Jak2_Jak3_rpt2cd050814e-1528701153
PTKc_Chkcd050833e-438701152
PTKc_Jak1_rpt2cd050792.1e-2378701153
PTKc_EGFRcd051082e-268701154
PTKc_HER4cd051106.3e-298701150
PTK_HER3cd051112e-388701154
PTKc_Itkcd051123.7e-398701150
PTKc_HER2cd051092.3e-378701154
PTKc_Btk_Bmxcd051134.2e-468701150
PTKc_Tec_Rlkcd051144.7e-408701150
STKc_MAP4K3_likecd066132.6e-108701122
STKc_MST1_2cd066121.1e-118701146
PKc_MKK4cd066163.5e-058701153
STKc_MAPK15cd078524.7e-088701153
STKc_CDK12cd078641.1e-108701150
STKc_PCTAIRE3cd078718.7e-078701151
STKc_CDKL5cd078480.000268711151
PTKc_RETcd050451e-328721154
STKc_ROCK_NDR_likecd055730.000838721150
PKc_MAPKK_Pek1_likecd066216.8e-108721132
STKc_MEKK3_like_1cd066537.9e-118721151
STKc_CDC2L1cd078433.5e-078721142
STKc_CDKL1_4cd078472e-098721151
STKc_Nek6_Nek7cd082249.7e-088721154
STKc_phototropin_likcd055740.000298731128
STKc_PKAcd055801.6e-098731125
STKc_PRKX_likecd056121.5e-068731153
PKc_MEKcd066154.3e-078731153
STKc_Cdc7_likecd066271.5e-168731146
STKc_MST3_likecd066091.1e-118731115
STKc_NAK1_likecd069172e-088731150
STKc_CDK7cd078411.6e-138731146
STKc_MPK1cd078577.6e-068731152
STKc_CDK1_eukcd078613.5e-128731151
STKc_CDK6cd078625.1e-068731151
STKc_Nek11cd082221.6e-068731151
STKc_CNK2-likecd085301.2e-088731152
PKc_STEcd051222.2e-148741149
STKc_GRK4_likecd056050.000428741153
STKc_MAPKKKcd066065.8e-268741151
STKc_YSK4cd066314.1e-108741143
STKc_MAPKcd078342.9e-078741152
STKc_CDK8_likecd078427.2e-088741150
STKc_CDK2_3cd078601.3e-108741149
STKc_CDC2L6cd078670.000338741150
STKc_Nekcd082151.5e-148741152
PTKc_Axl_likecd050351.6e-368751153
PTKc_Tyro3cd050741.5e-378751153
PTKc_Axlcd050752.9e-218751153
STKc_CMGCcd051182.3e-148751142
STKc_MSK_Ncd055837e-058751148
STKc_PKNcd055890.00038751152
STKc_MSK1_Ncd056130.000948751136
PKc_MAPKKcd066054e-108751151
PKc_MAPKK_Byr1_likecd066201.2e-068751154
STKc_MEKK3cd066518.3e-148751128
PKc_MAPKK_PBS2_likecd066220.00088751154
STKc_CDK_likecd078294.3e-168751149
STKc_MAK_likecd078305e-118751142
STKc_CDK1_likecd078353.9e-128751151
STKc_Pho85cd078363e-118751149
STKc_CDK4_6_likecd078381.5e-088751142
STKc_MOKcd078312.4e-098751149
STKc_CDK9_likecd078403.4e-118751142
STKc_CDK4cd078632e-078751150
STKc_Nek3cd082193.4e-098751132
STKc_Nek5cd082252.4e-058751153
STKc_Nek6cd082287.4e-068751152
STKc_Nek7cd082295.6e-088751151
STKc_Nek1cd082182.2e-078751153
PTK_Rykcd050439.9e-218761152
STKc_PDK1cd055811e-088761154
STKc_OSR1_SPAKcd066102.9e-108761149
STKc_MEKK3_likecd066256.3e-218761151
STKc_MAPKKK_Byr2_likcd066281.3e-198761153
STKc_CCRKcd078321.4e-108761143
STKc_CDKLcd078331.1e-098761149
STKc_CdkB_plantcd078371.1e-118761150
STKc_CDK5cd078391.4e-078761149
STKc_CDKL2_3cd078461.5e-088761149
PK_STRADcd082160.000418761154
STKc_Nek2cd082171.3e-078761151
STKc_Nek8cd082201.2e-078761133
STKc_Nek9cd082212.5e-078761151
PTKc_Tie1cd050891.9e-188771154
STKc_MEKK4cd066263.3e-088771151
PTKc_Csk_likecd050391.8e-238781152
PTKc_Srm_Brkcd051481.7e-378781152
STKc_RSK_Ncd055820.000298781152
STKc_myosinIII_likecd066085.5e-088781105
STKc_Nek4cd082231.2e-068781151
STKc_Nek10cd085284.5e-068781148
STKc_FA2-likecd085292.5e-078781152
PTKccd001929.8e-1008791150
PTKc_Ack_likecd050402.1e-548791151
PTKc_Fes_likecd050414.6e-388791151
PTKc_Aatykcd050426.8e-128791142
PTKc_c-roscd050444.7e-408791151
PTKc_Met_Roncd050581.6e-518791154
PTKc_Syk_likecd050601.2e-568791154
PTKc_Fescd050842e-428791151
PTKc_Aatyk2cd050861.2e-088791151
PTKc_Aatyk1_Aatyk3cd050872.1e-158791151
PTKc_Sykcd051166.6e-548791154
STKc_PKCcd055706.7e-078791152
STKc_PKB_alphacd055940.000928791151
STKc_nPKC_thetacd056196.6e-058791154
PTKc_Tiecd050475.1e-348801154
PTKc_Zap-70cd051152.6e-548801154
PKccd001801.1e-598811149
PTKc_Fercd050852.7e-418811151
STKc_AGCcd051232.8e-098811152
STKc_cGK_PKGcd055721.1e-068811148
STKc_GRKcd055770.000748811122
STKc_MAST_likecd055799e-088811116
STKc_GRK1cd056084.1e-058811122
STKc_MEKK1_plantcd066323.1e-138811147
STKc_MAPKKK_Bck1_likcd066293.1e-098821150
STKc_MEKK1cd066309.1e-088851150
Pkinasepfam000697.9e-12583845
Pkinasepfam000696e-358751149
B41smart002951.6e-8133286
SH2smart002522.3e-14437532
Pkinase_Tyrpfam077145.1e-82583845
TyrKcsmart002195e-15583845
STYKcsmart002212.9e-15583847
S_TKcsmart002202.8e-10609847
Pkinase_Tyrpfam077146.5e-1428751149
TyrKcsmart002193.9e-1418751149
STYKcsmart002211.1e-548751122
S_TKcsmart002204.7e-528851153

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_041715Polymorphismp.ASN973LYSN/A



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