Results for the protein: Q12851

Results for the Protein: Q12851

215274019

5871

MAP4K2

NCBI, UniProt

M4K2_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase kinase 2; AltName: Full=B lymphocyte serine/threonine-protein kinase; AltName: Full=Germinal center kinase; Short=GC kinase; AltName: Full=MAPK/ERK kinase kinase kinase 2; Short=MEK kinase kinase 2; Short=MEKKK 2; AltName: Full=Rab8-interacting protein

			0 2 0 2 0

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Swiss-Prot Protein: Q12851

Identical to: NP_004570

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_FGFR2	cd05101	1.5e-06	1	277
PTKc_HER2	cd05109	0.00052	1	284
PTK_HER3	cd05111	1.3e-05	1	284
STKc_ROCK	cd05596	1.5e-05	1	336
STKc_TAO3	cd06633	3e-50	1	311
STKc_myosinIIIA	cd06638	1.3e-75	1	273
STKc_myosinIIIB	cd06639	2.9e-68	1	274
STKc_STK10_LOK	cd06644	6.6e-79	1	293
STKc_PAK_II	cd06648	3.3e-64	1	286
STKc_PAK1	cd06654	3.9e-59	1	296
STKc_PAK2	cd06655	1.3e-58	1	297
STKc_PAK3	cd06656	1.6e-60	1	298
STKc_PAK4	cd06657	5.3e-51	1	292
STKc_PAK5	cd06658	2.8e-51	1	290
STKc_PAK6	cd06659	4.2e-59	1	293
STKc_PAK_I	cd06647	4.3e-70	1	294
STKc_p38alpha_MAPK14	cd07877	1.7e-05	1	327
STKc_ROCK2	cd05621	2.3e-05	2	341
STKc_ROCK1	cd05622	0.00029	2	342
STKc_PAK	cd06614	4.8e-96	2	286
STKc_TAO1	cd06635	3.9e-50	2	311
STKc_MAP4K4_6	cd06636	2.5e-81	2	273
STKc_CDK10	cd07845	6.4e-16	2	292
STKc_JNK3	cd07874	0.00019	2	337
STKc_JNK2	cd07876	0.00012	2	312
STKc_p38delta_MAPK13	cd07879	0.00082	2	340
PTKc_FGFR	cd05053	2.1e-07	3	282
PTKc_FGFR4	cd05099	1.2e-07	3	298
PTKc_FGFR3	cd05100	4.4e-05	3	308
STKc_ASK	cd06624	6.8e-44	3	273
STKc_JNK	cd07850	2.5e-06	3	305
STKc_CDK9	cd07865	4.4e-11	3	273
STKc_p38gamma_MAPK12	cd07880	4.3e-07	3	335
PKc_MKK7	cd06618	1.3e-17	4	288
STKc_p38	cd07851	5.4e-09	4	319
STKc_BUR1	cd07866	6.1e-10	4	273
STKc_p38beta_MAPK11	cd07878	0.00011	4	334
PTKc_EphR_B	cd05065	0.00049	6	268
PTKc_TrkA	cd05092	0.00041	6	283
STKc_TAO	cd06607	2.4e-63	6	310
STKc_TAO2	cd06634	2.7e-51	6	312
STKc_MAP4K3	cd06645	2.4e-188	6	272
STKc_MAP4K5	cd06646	1.2e-181	6	272
PKc_MAPKK_Byr1_like	cd06620	4.2e-17	6	280
PTKc_FAK	cd05056	1.4e-08	7	279
PTKc_EGFR_like	cd05057	3.1e-05	8	284
PTKc_Tie2	cd05088	0.00039	8	302
PKc_MEK2	cd06649	8.3e-10	8	298
PKc_MEK1	cd06650	4.2e-09	8	330
STKc_Sty1_Hog1	cd07856	1e-08	8	289
PTKc_ALK_LTK	cd05036	8.5e-10	9	274
PTK_Ryk	cd05043	3.7e-06	9	250
PTKc_InsR	cd05061	2e-06	9	277
PTKc_IGF-1R	cd05062	0.00031	9	273
PTKc_Yes	cd05069	1.4e-06	9	275
PTKc_Src	cd05071	1e-05	9	273
PTKc_Lyn	cd05072	2.3e-05	9	272
PTKc_Hck	cd05073	1.3e-05	9	272
STKc_myosinIII_like	cd06608	2.1e-109	9	273
STKc_TNIK	cd06637	3.1e-83	9	273
PTKc_Ror	cd05048	1.9e-05	10	242
PTKc_DDR	cd05051	0.00026	10	252
PTKc_Ror1	cd05090	3.6e-05	10	270
PTKc_DDR2	cd05095	0.00021	10	273
PTKc_DDR_like	cd05097	0.00018	10	273
STKc_SLK_like	cd06611	2.4e-98	10	288
STKc_SLK	cd06643	2.3e-77	10	291
STKc_PCTAIRE_like	cd07844	1e-08	10	305
STKc_ERK1_2_like	cd07849	1.1e-08	10	320
STKc_MAPK4_6	cd07854	5.4e-06	10	322
STKc_CDK12	cd07864	3.6e-14	10	273
PTKc_Itk	cd05112	2.6e-06	11	272
PTKc_Btk_Bmx	cd05113	6.8e-08	11	272
PTKc_Tec_Rlk	cd05114	7.5e-06	11	272
STKc_MST4	cd06640	4.6e-87	11	293
STKc_MST3	cd06641	9.2e-85	11	293
STKc_STK25-YSK1	cd06642	2.8e-90	11	293
STKc_TEY_MAPK_plant	cd07858	2.5e-08	11	327
STKc_PFTAIRE2	cd07870	5.9e-07	11	273
PTKc_InsR_like	cd05032	7.9e-07	12	270
PTKc_Src_like	cd05034	6.2e-09	12	275
PTKc_Csk_like	cd05039	3.2e-07	12	226
PTK_CCK4	cd05046	0.00035	12	273
PTKc_Trk	cd05049	5.7e-07	12	252
PTKc_Musk	cd05050	3.1e-08	12	270
PTKc_Abl	cd05052	2.6e-07	12	272
PTKc_Lck_Blk	cd05067	0.00028	12	292
PTKc_Fyn_Yrk	cd05070	7e-05	12	275
PTKc_Frk_like	cd05068	1.3e-09	12	274
PTKc_EphR	cd05033	1.7e-05	12	247
PTKc_Srm_Brk	cd05148	4.9e-07	12	270
STKc_MST1_2	cd06612	1.1e-114	12	273
STKc_MAP4K3_like	cd06613	2.4e-204	12	272
STKc_MEKK3_like	cd06625	6.5e-45	12	273
PTKc_Tyk2_rpt2	cd05080	6.5e-08	13	276
PTKc_Csk	cd05082	9.4e-05	13	271
PTKc_TrkB	cd05093	0.00036	13	295
PTKc_TrkC	cd05094	0.00087	13	346
PKc_MKK4	cd06616	4.8e-15	13	286
STKc_MEKK2	cd06652	2.1e-26	13	274
STKc_MEKK3_like_1	cd06653	1.2e-33	13	273
STKc_ERK5	cd07855	5.1e-10	13	307
STKc_PFTAIRE1	cd07869	2.5e-05	13	287
PK_STRAD	cd08216	4.7e-16	13	287
STKc_Nek6_Nek7	cd08224	2.1e-17	13	276
PTKc_Tec_like	cd05059	9.4e-06	14	254
PTKc_Chk	cd05083	8.4e-06	14	274
STKc_ROCK_NDR_like	cd05573	1.7e-12	14	340
STKc_phototropin_lik	cd05574	3e-08	14	290
STKc_PKA	cd05580	5.2e-11	14	310
STKc_PDK1	cd05581	3.5e-14	14	273
STKc_DMPK_like	cd05597	3.3e-07	14	342
STKc_LATS	cd05598	4.4e-07	14	331
STKc_NDR_like	cd05599	7.1e-05	14	281
STKc_Sid2p_Dbf2p	cd05600	3.3e-07	14	341
STKc_MAST	cd05609	3.4e-08	14	308
STKc_PRKX_like	cd05612	1.1e-09	14	308
STKc_MRCK_alpha	cd05623	7.9e-06	14	329
STKc_MRCK_beta	cd05624	6.9e-06	14	335
STKc_LATS2	cd05626	0.00011	14	336
STKc_NDR2	cd05627	1.8e-06	14	363
STKc_NDR1	cd05628	4.7e-07	14	344
STKc_NDR_like_fungal	cd05629	0.00029	14	346
STKc_CRIK	cd05601	3.7e-10	14	338
STKc_LATS1	cd05625	1.8e-05	14	336
PKc_MAPKK	cd06605	6.2e-44	14	278
STKc_MST3_like	cd06609	1.7e-114	14	293
PKc_MEK	cd06615	2.4e-17	14	286
PKc_MKK3_6	cd06617	1.7e-18	14	287
PKc_MKK5	cd06619	1.4e-23	14	289
STKc_OSR1_SPAK	cd06610	1.5e-72	14	273
PKc_MAPKK_Pek1_like	cd06621	8.1e-28	14	286
PKc_MAPKK_PBS2_like	cd06622	1.5e-24	14	317
STKc_NAK1_like	cd06917	1.1e-65	14	290
STKc_CDKL	cd07833	7.3e-15	14	273
STKc_CdkB_plant	cd07837	4.1e-12	14	274
STKc_CDC2L1	cd07843	5.2e-13	14	273
STKc_CDKL2_3	cd07846	1.5e-12	14	273
STKc_CDKL1_4	cd07847	2.5e-24	14	273
STKc_CDKL5	cd07848	2e-05	14	273
STKc_CDK6	cd07862	1.3e-05	14	273
STKc_PCTAIRE3	cd07871	7.7e-07	14	273
STKc_PCTAIRE2	cd07872	4.7e-06	14	295
STKc_PCTAIRE1	cd07873	4.5e-06	14	287
STKc_Nek6	cd08228	1.3e-18	14	277
STKc_Nek7	cd08229	1.9e-12	14	276
SPS1	COG0515	1.4e-57	14	446
PTKc_Jak_rpt2	cd05038	1.1e-09	15	276
PTKc_RET	cd05045	0.00048	15	271
PTKc_Tie1	cd05089	0.00067	15	295
PKc_STE	cd05122	2e-143	15	272
STKc_Yank1	cd05578	3.3e-15	15	273
STKc_MSK_N	cd05583	5.5e-10	15	292
STKc_cPKC	cd05587	5.3e-14	15	336
STKc_GRK4_like	cd05605	1.3e-08	15	299
STKc_MSK1_N	cd05613	2.9e-08	15	292
STKc_MSK2_N	cd05614	7.1e-10	15	340
STKc_cPKC_alpha	cd05615	7.2e-10	15	344
STKc_cPKC_beta	cd05616	3.7e-08	15	339
STKc_GRK6	cd05630	5.8e-06	15	294
STKc_GRK4	cd05631	3.7e-06	15	297
STKc_GRK5	cd05632	1.5e-07	15	292
STKc_MAPKKK	cd06606	2.8e-76	15	273
STKc_MEKK4	cd06626	7.3e-26	15	273
STKc_Cdc7_like	cd06627	3e-76	15	273
STKc_MAPKKK_Byr2_lik	cd06628	2.5e-47	15	273
STKc_MEKK3	cd06651	4.2e-33	15	277
STKc_CCRK	cd07832	5.2e-14	15	274
STKc_MAPK	cd07834	9e-11	15	309
STKc_Pho85	cd07836	3e-16	15	273
STKc_CDK5	cd07839	1.4e-12	15	273
STKc_CDK7	cd07841	2.3e-16	15	278
STKc_CDK8_like	cd07842	1.9e-11	15	273
STKc_MAPK15	cd07852	7e-11	15	310
STKc_NLK	cd07853	1.7e-05	15	340
STKc_MPK1	cd07857	1.6e-07	15	318
STKc_TDY_MAPK_plant	cd07859	1.1e-08	15	351
STKc_CDK2_3	cd07860	1.7e-13	15	273
STKc_CDK1_euk	cd07861	6e-13	15	273
STKc_CDK4	cd07863	1.4e-08	15	273
STKc_Nek	cd08215	1e-45	15	273
STKc_Nek2	cd08217	1.7e-17	15	273
STKc_Nek1	cd08218	2e-31	15	273
STKc_Nek3	cd08219	3.4e-26	15	273
STKc_Nek8	cd08220	1.2e-19	15	273
STKc_Nek11	cd08222	2.8e-22	15	273
STKc_Nek4	cd08223	6.1e-21	15	273
STKc_Nek5	cd08225	5.6e-36	15	273
STKc_Nek9	cd08221	2.3e-13	15	273
STKc_Nek10	cd08528	3.1e-10	15	270
STKc_CNK2-like	cd08530	1.5e-14	15	273
STKc_FA2-like	cd08529	9.6e-18	15	273
PTKc_Axl_like	cd05035	6.7e-05	16	275
PTKc_Tyro3	cd05074	5.5e-05	16	275
PTKc_Jak1_rpt2	cd05079	2e-05	16	276
PTKc_Jak2_Jak3_rpt2	cd05081	2e-07	16	275
STKc_CMGC	cd05118	4.7e-17	16	273
STKc_PKN	cd05589	1.2e-09	16	338
STKc_MAPKKK_Bck1_lik	cd06629	3.1e-21	16	273
STKc_CDK_like	cd07829	3.5e-18	16	273
STKc_MAK_like	cd07830	5.3e-17	16	273
STKc_MOK	cd07831	5.1e-11	16	273
STKc_CDK1_like	cd07835	4.1e-12	16	273
STKc_CDK4_6_like	cd07838	6.8e-15	16	273
STKc_CDK9_like	cd07840	6.9e-15	16	273
STKc_CDC2L6	cd07867	7.6e-07	16	273
STKc_CDK8	cd07868	1.9e-06	16	273
PTKc_Fer	cd05085	2.6e-07	17	274
PKc_MAPKK_plant_like	cd06623	6.4e-47	17	279
PK_STRAD_beta	cd08226	6.2e-07	17	287
PK_STRAD_alpha	cd08227	3.2e-08	17	288
STKc_YSK4	cd06631	1.4e-32	18	273
STKc_RSK_N	cd05582	1.2e-07	19	342
STKc_p70S6K	cd05584	1.7e-09	19	340
STKc_Rim15_like	cd05611	1.6e-07	19	338
PTKc	cd00192	2.5e-13	20	272
PTK_Jak_rpt1	cd05037	0.00069	20	272
PTKc_Ack_like	cd05040	7.4e-10	20	269
PTKc_Fes_like	cd05041	7.6e-14	20	242
PTKc_Aatyk	cd05042	3.9e-05	20	270
PTKc_c-ros	cd05044	2.1e-05	20	249
PTKc_Tie	cd05047	0.00051	20	282
PTKc_Met_Ron	cd05058	0.00017	20	277
PTKc_Syk_like	cd05060	0.00025	20	279
PTK_Jak1_rpt1	cd05077	0.00054	20	272
PTKc_Fes	cd05084	1.9e-09	20	273
PTKc_Aatyk2	cd05086	9.1e-05	20	270
PTKc_Aatyk1_Aatyk3	cd05087	0.00013	20	272
PTKc_Syk	cd05116	8.4e-06	20	273
STKc_PKB	cd05571	2e-12	20	340
STKc_SGK	cd05575	1.2e-06	20	338
STKc_aPKC	cd05588	7.2e-09	20	344
STKc_nPKC_eta	cd05590	3.2e-08	20	339
STKc_nPKC_epsilon	cd05591	8.4e-10	20	339
STKc_nPKC_theta_delt	cd05592	1.3e-09	20	340
STKc_PKB_alpha	cd05594	7.5e-11	20	341
STKc_PKB_beta	cd05595	1.8e-08	20	340
STKc_PKB_gamma	cd05593	1.3e-08	20	343
STKc_SGK1	cd05602	1.4e-06	20	341
STKc_SGK2	cd05603	3.5e-08	20	339
STKc_SGK3	cd05604	2.6e-05	20	341
STKc_aPKC_zeta	cd05617	1.2e-07	20	344
STKc_aPKC_iota	cd05618	7.7e-06	20	371
STKc_nPKC_theta	cd05619	2e-09	20	340
STKc_nPKC_delta	cd05620	2.3e-05	20	340
STKc_MEKK1	cd06630	1.7e-14	20	274
STKc_MEKK1_plant	cd06632	6.2e-54	20	273
PTKc_Zap-70	cd05115	1.7e-05	21	276
STKc_PKC	cd05570	2.6e-12	21	316
PKc	cd00180	1.3e-72	22	271
STKc_AGC	cd05123	7.3e-15	22	273
STKc_cGK_PKG	cd05572	6.3e-12	22	276
STKc_GRK	cd05577	2.8e-09	22	287
STKc_Sck1_like	cd05586	3.3e-08	22	383
STKc_YPK1_like	cd05585	1.7e-08	22	337
STKc_beta_ARK	cd05606	9.8e-08	22	297
STKc_GRK7	cd05607	1e-06	22	293
STKc_GRK1	cd05608	1.2e-09	22	293
STKc_MAST_like	cd05579	2.1e-15	22	273
STKc_GRK3	cd05633	3.1e-06	22	329
Pkinase	pfam00069	6.1e-75	16	273
CNH	pfam00780	8e-89	492	790
Pkinase_Tyr	pfam07714	2.4e-18	16	271
TyrKc	smart00219	1.7e-15	16	271
STYKc	smart00221	1.5e-82	16	273
S_TKc	smart00220	3.1e-87	26	273
KIND	smart00750	2.2e-28	96	281
CNH	smart00036	1.9e-131	487	800

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs115646677	Polymorphism	p.ALA120SER	N/A
dbSNP	rs34264803	Polymorphism	p.ARG580HIS	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258