Results for the protein: Q16512

Results for the Protein: Q16512

259016304

5585

PKN1

NCBI, UniProt

PKN1_HUMAN RecName: Full=Serine/threonine-protein kinase N1; AltName: Full=Protease-activated kinase 1; Short=PAK-1; AltName: Full=Protein kinase C-like 1; AltName: Full=Protein kinase C-like PKN; AltName: Full=Protein kinase PKN-alpha; AltName: Full=Protein-kinase C-related kinase 1; AltName: Full=Serine-threonine protein kinase N

			0 10 0 2 8

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Swiss-Prot Protein: Q16512

Identical to: NP_002732

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
HR1	cd00089	4.8e-31	118	191
HR1	cd00089	1e-24	205	278
C2_PKN-like	cd08687	7.2e-137	326	518
C2_PKC_epsilon	cd04014	0.00018	372	480
STKc_ROCK2	cd05621	5.4e-35	575	939
STKc_ROCK1	cd05622	4.8e-33	575	940
STKc_ROCK	cd05596	2.1e-38	575	939
STKc_TAO1	cd06635	4e-06	590	885
PTKc_PDGFR	cd05055	2.1e-06	592	868
STKc_PAK4	cd06657	1.1e-07	593	898
STKc_PAK5	cd06658	6.1e-07	593	888
STKc_PAK6	cd06659	6.4e-10	593	902
STKc_PAK1	cd06654	1.8e-08	597	888
STKc_TAO2	cd06634	3.9e-06	598	918
STKc_PAK_I	cd06647	7e-08	598	902
STKc_PAK3	cd06656	2.5e-09	598	903
STKc_p38alpha_MAPK14	cd07877	0.00049	598	934
STKc_PAK	cd06614	8.4e-18	599	887
PKc_MKK7	cd06618	2.8e-10	600	876
STKc_TAO3	cd06633	0.00018	600	893
STKc_p38gamma_MAPK12	cd07880	6.8e-06	601	934
STKc_STK10_LOK	cd06644	4e-11	602	885
STKc_TAO	cd06607	4.4e-06	603	885
STKc_MAP4K4_6	cd06636	3.7e-06	603	874
STKc_p38beta_MAPK11	cd07878	0.0009	603	934
PTKc_DDR	cd05051	2.8e-05	604	860
PTKc_FGFR4	cd05099	4.4e-07	604	894
STKc_myosinIIIA	cd06638	1.7e-09	604	869
STKc_myosinIIIB	cd06639	3.4e-08	604	875
STKc_CDK9	cd07865	1.1e-06	604	874
PTKc_FGFR	cd05053	2.4e-07	605	884
PTKc_EGFR_like	cd05057	2.3e-07	605	895
PTKc_FGFR1	cd05098	3.5e-05	605	880
PTKc_FGFR3	cd05100	3.8e-05	605	911
PTKc_FGFR2	cd05101	7.6e-06	605	879
PTKc_EGFR	cd05108	3.7e-07	605	917
PTKc_HER4	cd05110	2.7e-06	605	900
STKc_MAP4K5	cd06646	2.2e-07	605	873
STKc_p38	cd07851	3.5e-07	605	906
PTKc_EphR_A2	cd05063	4.7e-05	606	873
STKc_ASK	cd06624	1.4e-16	606	874
STKc_MAP4K3	cd06645	3.9e-08	606	873
STKc_JNK	cd07850	7.5e-05	606	938
PTKc_VEGFR3	cd05102	8.2e-07	607	871
PTKc_VEGFR2	cd05103	6.2e-06	607	871
STKc_PAK_II	cd06648	4.8e-12	607	887
PTKc_ALK_LTK	cd05036	1.6e-09	608	866
PTKc_FAK	cd05056	4.1e-07	608	873
STKc_myosinIII_like	cd06608	2.7e-10	608	874
STKc_CDK12	cd07864	3.4e-08	608	874
PTKc_Ror	cd05048	3.3e-08	609	861
PTKc_Trk	cd05049	9.3e-08	609	866
PTKc_EphR_A10	cd05064	0.0003	609	871
PTK_CCK4	cd05046	4.9e-06	609	864
PTKc_Ror1	cd05090	2e-06	609	870
PTKc_DDR2	cd05095	0.00021	609	869
PTKc_DDR_like	cd05097	9.5e-05	609	884
PTKc_Ror2	cd05091	7e-06	609	877
PKc_MEK2	cd06649	2.7e-06	609	924
STKc_MEKK3	cd06651	1e-09	609	876
PKc_MEK1	cd06650	9.8e-06	609	928
PTKc_InsR_like	cd05032	9.7e-10	610	864
PTKc_EphR	cd05033	7.9e-07	610	850
PTKc_Jak_rpt2	cd05038	4e-10	610	885
PTKc_Csk_like	cd05039	4.2e-08	610	841
PTK_Ryk	cd05043	0.00049	610	843
PTKc_Abl	cd05052	5.2e-08	610	873
PTKc_Tec_like	cd05059	9.3e-09	610	883
PTKc_IGF-1R	cd05062	0.00013	610	864
PTKc_InsR	cd05061	1.1e-05	610	879
PTKc_EphR_B	cd05065	1.4e-05	610	875
PTKc_Lck_Blk	cd05067	1.8e-05	610	865
PTKc_Frk_like	cd05068	6.6e-09	610	868
PTKc_EphR_A	cd05066	0.00025	610	873
PTKc_Yes	cd05069	2.5e-06	610	868
PTKc_Src	cd05071	1.2e-05	610	870
PTKc_Lyn	cd05072	2.1e-10	610	865
PTKc_Hck	cd05073	7.1e-09	610	865
PTKc_Jak1_rpt2	cd05079	4.1e-05	610	869
PTKc_Chk	cd05083	1.5e-07	610	871
PTKc_Csk	cd05082	4.6e-07	610	871
PTKc_Tie2	cd05088	2.2e-08	610	889
PTKc_Fyn_Yrk	cd05070	6.9e-06	610	868
PTKc_TrkA	cd05092	6.8e-07	610	871
PTKc_TrkB	cd05093	1.9e-05	610	876
PTKc_TrkC	cd05094	0.001	610	884
PTKc_HER2	cd05109	2.4e-06	610	895
PTK_HER3	cd05111	6e-08	610	875
PTKc_Itk	cd05112	8.2e-09	610	868
PTKc_Btk_Bmx	cd05113	5.4e-10	610	868
PTKc_Tec_Rlk	cd05114	8.7e-09	610	869
PKc_MKK4	cd06616	8.9e-08	610	887
STKc_SLK	cd06643	1.1e-10	610	883
PKc_MAPKK_Byr1_like	cd06620	2.6e-09	610	905
STKc_ERK5	cd07855	1.7e-06	610	907
STKc_MAP4K3_like	cd06613	7.3e-15	611	873
STKc_PAK2	cd06655	1.7e-08	611	898
STKc_PCTAIRE_like	cd07844	1.1e-07	611	887
STKc_CDK10	cd07845	3.2e-11	611	896
STKc_Sty1_Hog1	cd07856	1.1e-06	611	920
STKc_PFTAIRE1	cd07869	7.9e-05	611	900
STKc_PFTAIRE2	cd07870	1e-06	611	887
STKc_PCTAIRE2	cd07872	3.8e-07	611	898
STKc_PCTAIRE1	cd07873	1.1e-06	611	889
STKc_CDC2L1	cd07843	7.4e-08	611	874
STKc_PCTAIRE3	cd07871	2.7e-07	611	874
STKc_BUR1	cd07866	2.1e-09	611	874
PTKc_Jak2_Jak3_rpt2	cd05081	1.5e-08	612	885
PTKc_Tie1	cd05089	3.2e-07	612	892
STKc_TNIK	cd06637	1.4e-07	612	874
STKc_Nek6_Nek7	cd08224	2.1e-08	612	870
STKc_Nek6	cd08228	1.5e-06	612	870
STKc_Nek7	cd08229	7.5e-09	612	874
PTKc_Src_like	cd05034	1.8e-09	613	865
PTKc_Musk	cd05050	1.7e-07	613	863
PTKc_Srm_Brk	cd05148	4.8e-09	613	861
STKc_phototropin_lik	cd05574	5.9e-52	613	900
STKc_ROCK_NDR_like	cd05573	5.4e-60	613	938
STKc_PKA	cd05580	4.1e-107	613	907
STKc_PDK1	cd05581	4.3e-60	613	874
STKc_DMPK_like	cd05597	1.7e-52	613	938
STKc_LATS	cd05598	1e-36	613	941
STKc_Sid2p_Dbf2p	cd05600	2.1e-19	613	939
STKc_CRIK	cd05601	1.1e-35	613	938
STKc_NDR_like	cd05599	1.7e-24	613	938
STKc_MAST	cd05609	4.2e-67	613	905
STKc_PRKX_like	cd05612	9.7e-85	613	908
STKc_MRCK_alpha	cd05623	5.3e-39	613	939
STKc_MRCK_beta	cd05624	3.4e-41	613	938
STKc_NDR2	cd05627	2.4e-26	613	941
STKc_NDR1	cd05628	9.1e-24	613	941
STKc_NDR_like_fungal	cd05629	4.9e-34	613	941
STKc_LATS2	cd05626	3.3e-27	613	941
PKc_MAPKK	cd06605	3.3e-12	613	876
STKc_MST3_like	cd06609	1.6e-13	613	891
STKc_OSR1_SPAK	cd06610	1.3e-13	613	874
STKc_MST1_2	cd06612	3.3e-15	613	874
PKc_MEK	cd06615	6.6e-12	613	942
PKc_MKK3_6	cd06617	1.2e-07	613	889
PKc_MKK5	cd06619	2.5e-05	613	886
PKc_MAPKK_Pek1_like	cd06621	2.5e-10	613	879
PKc_MAPKK_PBS2_like	cd06622	6.7e-09	613	912
PKc_MAPKK_plant_like	cd06623	8.3e-19	613	867
STKc_MEKK3_like	cd06625	1.2e-14	613	874
STKc_MST4	cd06640	1.5e-07	613	888
STKc_MST3	cd06641	2.1e-07	613	880
STKc_STK25-YSK1	cd06642	3.1e-08	613	880
STKc_MEKK2	cd06652	1.1e-06	613	875
STKc_MEKK3_like_1	cd06653	1.5e-08	613	870
STKc_NAK1_like	cd06917	1.1e-13	613	887
STKc_CDKL	cd07833	2.4e-09	613	874
STKc_CdkB_plant	cd07837	5.3e-11	613	875
STKc_CDKL2_3	cd07846	8e-10	613	874
STKc_CDKL1_4	cd07847	4.4e-08	613	874
STKc_CDKL5	cd07848	4e-05	613	874
STKc_ERK1_2_like	cd07849	3.4e-08	613	909
STKc_CDK6	cd07862	4.6e-06	613	900
SPS1	COG0515	1.4e-52	613	942
PTKc_RET	cd05045	9.6e-07	614	870
PKc_STE	cd05122	2.2e-28	614	873
STKc_Yank1	cd05578	6.4e-61	614	874
STKc_MSK_N	cd05583	5.6e-85	614	893
STKc_cPKC	cd05587	1.6e-136	614	939
STKc_GRK4_like	cd05605	6.5e-66	614	895
STKc_MSK1_N	cd05613	3.8e-65	614	893
STKc_MSK2_N	cd05614	6.2e-81	614	940
STKc_cPKC_alpha	cd05615	2.4e-120	614	939
STKc_cPKC_beta	cd05616	2.3e-121	614	939
STKc_GRK6	cd05630	2.3e-52	614	895
STKc_GRK5	cd05632	8.8e-60	614	895
STKc_GRK4	cd05631	2.7e-63	614	895
STKc_MAPKKK	cd06606	7.6e-40	614	874
STKc_Cdc7_like	cd06627	5.5e-17	614	874
STKc_CCRK	cd07832	2.5e-14	614	875
STKc_Pho85	cd07836	5.7e-07	614	874
STKc_CDK5	cd07839	5.2e-08	614	874
STKc_MAPK	cd07834	1.8e-09	614	928
STKc_CDK7	cd07841	9.8e-13	614	888
STKc_CDK8_like	cd07842	3e-06	614	874
STKc_MPK1	cd07857	3.6e-06	614	887
STKc_TEY_MAPK_plant	cd07858	1.8e-06	614	934
STKc_TDY_MAPK_plant	cd07859	1.3e-06	614	934
STKc_CDK2_3	cd07860	1e-06	614	892
STKc_NLK	cd07853	0.00016	614	935
STKc_CDK1_euk	cd07861	1.2e-05	614	874
STKc_CDK4	cd07863	4.5e-06	614	887
STKc_Nek	cd08215	4.4e-34	614	874
STKc_Nek2	cd08217	8.4e-13	614	863
STKc_Nek1	cd08218	5.6e-19	614	874
STKc_Nek3	cd08219	2e-20	614	869
STKc_Nek9	cd08221	1.1e-09	614	874
STKc_Nek11	cd08222	4e-22	614	874
STKc_Nek4	cd08223	5.9e-16	614	874
STKc_Nek5	cd08225	2e-21	614	874
STKc_Nek8	cd08220	1.7e-09	614	869
STKc_Nek10	cd08528	1e-07	614	866
STKc_FA2-like	cd08529	1.7e-12	614	874
STKc_CNK2-like	cd08530	5.6e-14	614	863
PTKc_Axl_like	cd05035	5.4e-07	615	869
PTKc_Tyro3	cd05074	2.6e-06	615	869
PTKc_Axl	cd05075	4e-05	615	872
PTKc_Tyk2_rpt2	cd05080	1.8e-08	615	903
STKc_CMGC	cd05118	2.7e-14	615	874
STKc_PKN	cd05589	1e-248	615	938
STKc_LATS1	cd05625	2.1e-25	615	941
STKc_MAPKKK_Bck1_lik	cd06629	8.4e-13	615	874
STKc_CDK_like	cd07829	8.3e-15	615	874
STKc_MOK	cd07831	3.7e-11	615	874
STKc_CDK1_like	cd07835	2.5e-07	615	887
STKc_MAK_like	cd07830	3.4e-12	615	874
STKc_CDK4_6_like	cd07838	8.6e-10	615	874
STKc_CDK9_like	cd07840	4.4e-11	615	874
STKc_MAPK4_6	cd07854	9e-07	615	929
STKc_MAPKKK_Byr2_lik	cd06628	5.3e-22	616	874
STKc_RSK_N	cd05582	1.2e-90	618	938
STKc_p70S6K	cd05584	4e-93	618	940
STKc_Rim15_like	cd05611	4.9e-17	618	880
STKc_MEKK4	cd06626	1.7e-12	618	868
PTKc	cd00192	1.8e-13	619	867
PTKc_Ack_like	cd05040	8.7e-11	619	869
PTKc_Fes_like	cd05041	8e-11	619	870
PTKc_c-ros	cd05044	1.9e-07	619	870
PTKc_Tie	cd05047	1.2e-06	619	866
PTKc_Met_Ron	cd05058	4.9e-07	619	871
PTKc_Syk_like	cd05060	2.5e-08	619	867
PTKc_Fes	cd05084	1.5e-07	619	869
PTKc_Fer	cd05085	5.8e-08	619	869
PTKc_Aatyk2	cd05086	0.0004	619	874
PTKc_Aatyk1_Aatyk3	cd05087	0.00087	619	874
PTKc_Zap-70	cd05115	5e-07	619	874
PTKc_Syk	cd05116	3.7e-07	619	875
STKc_PKC	cd05570	1e-214	619	938
STKc_PKB	cd05571	3.1e-126	619	940
STKc_SGK	cd05575	8.2e-104	619	938
STKc_aPKC	cd05588	3.7e-98	619	939
STKc_nPKC_epsilon	cd05591	9.3e-130	619	939
STKc_nPKC_theta_delt	cd05592	4.5e-130	619	940
STKc_PKB_gamma	cd05593	5.9e-100	619	941
STKc_PKB_alpha	cd05594	6.8e-108	619	941
STKc_nPKC_eta	cd05590	1.9e-128	619	939
STKc_PKB_beta	cd05595	2.7e-112	619	940
STKc_SGK1	cd05602	5.9e-78	619	940
STKc_SGK3	cd05604	3e-88	619	940
STKc_aPKC_zeta	cd05617	1.8e-82	619	939
STKc_SGK2	cd05603	3.1e-93	619	939
STKc_nPKC_theta	cd05619	1.3e-125	619	940
STKc_nPKC_delta	cd05620	2.3e-117	619	940
STKc_aPKC_iota	cd05618	2.2e-82	619	939
STKc_YSK4	cd06631	4.5e-10	619	874
STKc_MEKK1	cd06630	1.9e-11	619	875
STKc_beta_ARK	cd05606	9.7e-54	620	894
STKc_GRK3	cd05633	4.6e-43	620	895
STKc_MEKK1_plant	cd06632	1.5e-14	620	874
PKc	cd00180	3e-67	621	872
PTKc_Aatyk	cd05042	1e-05	621	852
STKc_AGC	cd05123	3.2e-115	621	874
STKc_cGK_PKG	cd05572	3.8e-77	621	881
STKc_GRK	cd05577	7.9e-70	621	894
STKc_MAST_like	cd05579	1.3e-54	621	879
STKc_YPK1_like	cd05585	2.6e-92	621	937
STKc_Sck1_like	cd05586	2.5e-77	621	937
STKc_GRK7	cd05607	1.7e-53	621	894
STKc_GRK1	cd05608	8.9e-74	621	894
STKc_SLK_like	cd06611	1e-12	621	885
STKc_MAPK15	cd07852	1e-06	662	912
HR1	pfam02185	2.7e-17	38	96
HR1	pfam02185	1e-20	127	189
HR1	pfam02185	2.5e-18	214	276
Pkinase	pfam00069	2.4e-80	615	874
Pkinase_C	pfam00433	2.4e-14	894	941
Hr1	smart00742	6.8e-19	37	93
Hr1	smart00742	7.1e-22	126	186
Hr1	smart00742	4.8e-22	213	273
Pkinase_Tyr	pfam07714	1.5e-17	615	868
TyrKc	smart00219	4.4e-16	615	868
STYKc	smart00221	1.5e-83	615	874
S_TKc	smart00220	8.9e-97	625	874
S_TK_X	smart00133	6.1e-19	875	939

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_042338	Polymorphism	p.ALA197GLU	N/A
Swiss-Prot	VAR_042345	Polymorphism	p.ALA921VAL	N/A
Swiss-Prot	VAR_042337	Polymorphism	p.ARG185CYS	N/A
Swiss-Prot	VAR_042340	Polymorphism	p.ARG520GLN	N/A
Swiss-Prot	VAR_042342	Polymorphism	p.ARG635GLN	N/A
Swiss-Prot	VAR_042339	Polymorphism	p.ARG436TRP	N/A
dbSNP	rs2230539	Polymorphism	p.ILE718VAL	N/A
Swiss-Prot	VAR_042341	Polymorphism	p.LEU555ILE	N/A
Swiss-Prot	VAR_042344	Polymorphism	p.PHE873LEU	N/A
dbSNP	rs10846	Polymorphism	p.VAL901ILE	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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