Results for the protein: O75914

Results for the Protein: O75914

47117818

5063

PAK3

NCBI, UniProt

PAK3_HUMAN RecName: Full=Serine/threonine-protein kinase PAK 3; AltName: Full=Beta-PAK; AltName: Full=Oligophrenin-3; AltName: Full=p21-activated kinase 3; Short=PAK-3

Known Diseases associated with this Protein:
MENTAL RETARDATION, X-LINKED 30
MENTAL RETARDATION, X-LINKED 30 (MRX30)

6

1

4

0

3

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Swiss-Prot Protein: O75914

Identical to: NP_001121645

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
CRIB_PAK_like	cd01093	5.2e-20	68	128
STKc_ROCK2	cd05621	8.6e-08	241	559
STKc_ROCK1	cd05622	2.5e-06	242	559
STKc_ROCK	cd05596	1.4e-07	246	559
STKc_JNK1	cd07875	9.5e-07	252	557
STKc_TAO1	cd06635	9.4e-51	253	559
STKc_TAO3	cd06633	1.2e-50	257	559
STKc_PAK5	cd06658	8.7e-120	260	551
PTKc_FGFR1	cd05098	6.4e-05	261	545
STKc_PAK6	cd06659	2.1e-116	261	557
STKc_PAK1	cd06654	3.3e-269	262	557
STKc_PAK4	cd06657	1.9e-119	262	553
STKc_TAO	cd06607	5.5e-63	263	557
STKc_PAK	cd06614	1.7e-206	263	547
STKc_TAO2	cd06634	5.3e-49	263	558
STKc_PAK_II	cd06648	4.9e-154	263	547
STKc_PAK_I	cd06647	8.7e-245	263	555
STKc_PAK2	cd06655	5.1e-254	263	559
STKc_PAK3	cd06656	1.4e-281	263	559
STKc_myosinIIIB	cd06639	7.4e-53	265	535
STKc_JNK2	cd07876	1.2e-07	265	559
STKc_p38alpha_MAPK14	cd07877	6.5e-06	265	558
STKc_myosinIIIA	cd06638	5.6e-59	266	534
STKc_STK10_LOK	cd06644	1e-60	267	554
STKc_p38	cd07851	1.5e-11	267	559
STKc_p38beta_MAPK11	cd07878	1.2e-06	267	556
STKc_p38delta_MAPK13	cd07879	9e-05	267	558
STKc_JNK3	cd07874	5.2e-07	268	559
PTKc_PDGFR	cd05055	0.00065	269	536
PTKc_FGFR2	cd05101	4e-05	269	541
PTKc_HER4	cd05110	6.2e-06	270	559
PTKc_FGFR4	cd05099	8e-06	270	546
STKc_JNK	cd07850	7.5e-10	270	558
STKc_CDK9	cd07865	1.1e-12	270	534
STKc_p38gamma_MAPK12	cd07880	2.3e-07	270	558
STKc_MAP4K4_6	cd06636	6.3e-58	271	534
PKc_MKK7	cd06618	2.7e-15	273	550
STKc_ASK	cd06624	7.2e-44	274	534
STKc_MAP4K3	cd06645	2.3e-69	274	533
STKc_MAP4K5	cd06646	3.3e-65	274	533
STKc_CDK10	cd07845	2.7e-13	275	545
STKc_ERK5	cd07855	1.8e-09	275	557
STKc_Sty1_Hog1	cd07856	1.8e-10	275	550
PTKc_FAK	cd05056	3.3e-08	276	538
STKc_myosinIII_like	cd06608	3.5e-77	276	534
STKc_TNIK	cd06637	6.8e-57	276	534
STKc_BUR1	cd07866	2.8e-10	276	534
STKc_PFTAIRE2	cd07870	1.6e-08	276	534
PTKc_FGFR3	cd05100	0.00078	277	558
STKc_SLK_like	cd06611	1.7e-66	277	546
STKc_SLK	cd06643	1.5e-67	277	552
STKc_PCTAIRE1	cd07873	7.7e-07	277	545
STKc_PCTAIRE2	cd07872	1.7e-07	277	551
PTKc_Ror	cd05048	1.3e-06	278	486
PTKc_FGFR	cd05053	3.2e-07	278	537
PTKc_EphR_A10	cd05064	0.00016	278	540
PTKc_Itk	cd05112	1.7e-09	278	533
PTKc_Tec_Rlk	cd05114	1.1e-08	278	533
STKc_MST4	cd06640	7.8e-81	278	554
STKc_MST3	cd06641	1.6e-78	278	554
STKc_STK25-YSK1	cd06642	2.7e-80	278	554
STKc_PCTAIRE_like	cd07844	6.9e-14	278	559
STKc_ERK1_2_like	cd07849	1.4e-08	278	559
STKc_MAPK4_6	cd07854	5.4e-08	278	558
STKc_TEY_MAPK_plant	cd07858	2.2e-06	278	558
PTKc_InsR_like	cd05032	4.7e-09	279	536
PTKc_EphR	cd05033	1.3e-06	279	537
PTKc_Src_like	cd05034	9.1e-08	279	510
PTKc_Jak_rpt2	cd05038	1.4e-09	279	537
PTKc_Csk_like	cd05039	7.9e-07	279	489
PTKc_Trk	cd05049	1.2e-05	279	531
PTKc_Musk	cd05050	1.4e-07	279	531
PTKc_Abl	cd05052	3.4e-08	279	537
PTKc_ALK_LTK	cd05036	4.8e-11	279	534
PTKc_InsR	cd05061	1.1e-07	279	543
PTKc_IGF-1R	cd05062	2.3e-07	279	536
PTKc_Lck_Blk	cd05067	1.3e-05	279	543
PTKc_Frk_like	cd05068	5.7e-11	279	536
PTKc_Yes	cd05069	9.6e-07	279	537
PTKc_Fyn_Yrk	cd05070	8.9e-06	279	537
PTKc_Src	cd05071	2.8e-05	279	539
PTKc_Lyn	cd05072	8.6e-05	279	536
PTKc_Hck	cd05073	1.3e-05	279	536
PTKc_Tie2	cd05088	7.8e-05	279	556
PTKc_Ror1	cd05090	4.7e-05	279	537
PTKc_DDR2	cd05095	0.00015	279	525
PTKc_DDR_like	cd05097	0.0002	279	536
PTKc_Btk_Bmx	cd05113	3.7e-10	279	533
PTKc_Srm_Brk	cd05148	1.7e-07	279	543
STKc_MST1_2	cd06612	2.4e-90	279	534
STKc_MAP4K3_like	cd06613	7.1e-105	279	533
PTKc_Tec_like	cd05059	1.5e-09	280	533
PTKc_EphR_B	cd05065	0.0001	280	537
PTKc_EphR_A	cd05066	0.00031	280	537
PTKc_Jak1_rpt2	cd05079	5.8e-05	280	537
PTKc_Tyk2_rpt2	cd05080	7.6e-07	280	539
PTKc_Jak2_Jak3_rpt2	cd05081	1.3e-08	280	538
PTKc_Csk	cd05082	6.5e-08	280	532
PTKc_TrkA	cd05092	2.6e-05	280	538
PTK_HER3	cd05111	1.9e-07	280	549
PKc_MEK2	cd06649	1.3e-07	280	549
PKc_MEK1	cd06650	1.8e-07	280	557
STKc_MEKK3_like_1	cd06653	1.6e-30	280	534
STKc_PFTAIRE1	cd07869	5.4e-05	280	545
STKc_Nek6_Nek7	cd08224	2.7e-15	280	542
PTKc_EphR_A2	cd05063	0.00021	281	537
PTKc_TrkB	cd05093	6.1e-05	281	549
PTKc_Chk	cd05083	1.5e-07	281	539
STKc_ROCK_NDR_like	cd05573	1.1e-14	281	559
STKc_phototropin_lik	cd05574	2.3e-11	281	556
STKc_PKA	cd05580	1.7e-16	281	552
STKc_PDK1	cd05581	5e-23	281	534
STKc_DMPK_like	cd05597	7.4e-07	281	559
STKc_Sid2p_Dbf2p	cd05600	5.1e-09	281	559
STKc_CRIK	cd05601	6.4e-10	281	559
STKc_LATS	cd05598	2.1e-08	281	559
STKc_MAST	cd05609	6.1e-11	281	557
STKc_MRCK_alpha	cd05623	2.9e-07	281	558
STKc_MRCK_beta	cd05624	1.9e-06	281	559
STKc_NDR2	cd05627	0.0002	281	558
STKc_NDR1	cd05628	8.3e-06	281	555
STKc_LATS2	cd05626	2.7e-05	281	559
STKc_PRKX_like	cd05612	2.1e-14	281	555
STKc_NDR_like_fungal	cd05629	5.4e-05	281	559
STKc_MST3_like	cd06609	1.9e-98	281	554
STKc_OSR1_SPAK	cd06610	7.8e-88	281	534
PKc_MEK	cd06615	2.7e-13	281	544
PKc_MKK3_6	cd06617	6.7e-17	281	549
PKc_MKK5	cd06619	1.3e-20	281	555
PKc_MAPKK_Pek1_like	cd06621	6.9e-18	281	544
PKc_MAPKK	cd06605	8.1e-25	281	539
PKc_MAPKK_PBS2_like	cd06622	2.5e-13	281	557
STKc_MEKK3_like	cd06625	2.3e-53	281	534
STKc_NAK1_like	cd06917	9.4e-78	281	551
STKc_CDKL	cd07833	4.7e-16	281	534
STKc_CdkB_plant	cd07837	3.9e-14	281	535
STKc_CDC2L1	cd07843	2.9e-13	281	534
STKc_CDKL2_3	cd07846	1.1e-14	281	534
STKc_CDKL1_4	cd07847	4.1e-32	281	534
STKc_CDKL5	cd07848	3.7e-06	281	534
STKc_MAPK15	cd07852	3.9e-12	281	559
STKc_CDK6	cd07862	6e-08	281	559
STKc_CDK12	cd07864	4e-13	281	534
STKc_PCTAIRE3	cd07871	1.5e-07	281	534
PK_STRAD	cd08216	6.8e-16	281	549
STKc_Nek6	cd08228	2.1e-18	281	536
STKc_Nek7	cd08229	5.6e-12	281	542
SPS1	COG0515	4.4e-47	281	559
PTKc_RET	cd05045	0.0001	282	540
PTKc_EGFR_like	cd05057	2.8e-07	282	549
PTKc_Tie1	cd05089	0.00013	282	556
PTKc_EGFR	cd05108	5.4e-07	282	556
PTKc_HER2	cd05109	6.2e-08	282	549
PKc_STE	cd05122	7.3e-152	282	533
STKc_Yank1	cd05578	1.3e-18	282	534
STKc_MSK_N	cd05583	7.2e-12	282	553
STKc_cPKC	cd05587	2.3e-07	282	559
STKc_GRK4_like	cd05605	5.1e-10	282	556
STKc_MSK1_N	cd05613	5.4e-08	282	545
STKc_MSK2_N	cd05614	1.1e-07	282	558
STKc_cPKC_alpha	cd05615	5e-08	282	556
STKc_cPKC_beta	cd05616	7.1e-06	282	559
STKc_GRK6	cd05630	2.3e-07	282	551
STKc_GRK4	cd05631	3.4e-07	282	551
STKc_GRK5	cd05632	1.9e-08	282	551
STKc_MAPKKK	cd06606	2.2e-87	282	534
PKc_MAPKK_Byr1_like	cd06620	1.4e-11	282	544
STKc_MEKK4	cd06626	2.1e-38	282	534
STKc_Cdc7_like	cd06627	4.3e-76	282	534
STKc_MAPKKK_Byr2_lik	cd06628	3.6e-54	282	534
STKc_MEKK1	cd06630	9.4e-30	282	535
STKc_YSK4	cd06631	1.8e-38	282	534
STKc_MAPKKK_Bck1_lik	cd06629	1e-21	282	534
STKc_MEKK3	cd06651	1e-36	282	536
STKc_CCRK	cd07832	5.1e-18	282	535
STKc_MAPK	cd07834	1.9e-12	282	557
STKc_Pho85	cd07836	1.9e-23	282	559
STKc_CDK7	cd07841	2.6e-19	282	548
STKc_CDK8_like	cd07842	1.1e-09	282	534
STKc_NLK	cd07853	8.3e-07	282	558
STKc_MPK1	cd07857	2.4e-08	282	554
STKc_TDY_MAPK_plant	cd07859	2.3e-08	282	558
STKc_CDK2_3	cd07860	3.3e-21	282	534
STKc_CDK1_euk	cd07861	5.4e-19	282	559
STKc_CDK4	cd07863	5.8e-12	282	534
STKc_CDK5	cd07839	1.7e-10	282	534
STKc_Nek	cd08215	2.2e-44	282	534
STKc_Nek2	cd08217	4.7e-20	282	534
STKc_Nek1	cd08218	1.5e-29	282	534
STKc_Nek3	cd08219	5.4e-19	282	534
STKc_Nek8	cd08220	1.1e-32	282	534
STKc_Nek9	cd08221	4.8e-18	282	534
STKc_Nek11	cd08222	1.8e-23	282	534
STKc_Nek4	cd08223	8.2e-21	282	534
STKc_Nek5	cd08225	3.7e-32	282	534
STKc_Nek10	cd08528	5.1e-18	282	527
STKc_FA2-like	cd08529	6.2e-18	282	534
PTKc_Tyro3	cd05074	6e-05	283	536
STKc_CMGC	cd05118	5.8e-19	283	534
STKc_PKN	cd05589	7.3e-10	283	559
PKc_MKK4	cd06616	1.9e-14	283	554
STKc_CDK_like	cd07829	7.9e-22	283	534
STKc_MAK_like	cd07830	4.3e-17	283	534
STKc_MOK	cd07831	5.5e-14	283	534
STKc_CDK4_6_like	cd07838	9.8e-17	283	534
STKc_CDK9_like	cd07840	5.4e-18	283	534
STKc_CDK1_like	cd07835	1.1e-18	283	559
PTKc_Axl_like	cd05035	6.7e-06	284	544
STKc_NDR_like	cd05599	7.4e-11	284	558
STKc_LATS1	cd05625	1.5e-05	284	558
PKc_MAPKK_plant_like	cd06623	2.9e-50	284	539
PK_STRAD_alpha	cd08227	6.5e-08	284	549
PTKc_c-ros	cd05044	1.1e-07	285	531
STKc_MEKK2	cd06652	2.4e-27	285	535
STKc_CNK2-like	cd08530	3.7e-15	285	534
STKc_RSK_N	cd05582	4.1e-06	286	558
STKc_p70S6K	cd05584	1.9e-09	286	559
STKc_CDC2L6	cd07867	0.00019	286	534
STKc_CDK8	cd07868	0.00011	286	534
PTKc	cd00192	3.4e-21	287	533
PTKc_Ack_like	cd05040	3.9e-09	287	530
PTKc_Fes_like	cd05041	1e-12	287	536
PTKc_Aatyk	cd05042	4.7e-06	287	531
PTKc_Tie	cd05047	5.8e-05	287	541
PTKc_Syk_like	cd05060	9.1e-07	287	545
PTK_Jak2_Jak3_rpt1	cd05078	0.00027	287	533
PTKc_Met_Ron	cd05058	1.2e-06	287	538
PTKc_Fes	cd05084	3.3e-08	287	534
PTKc_Fer	cd05085	2.8e-06	287	534
PTKc_Syk	cd05116	1.6e-06	287	534
STKc_PKC	cd05570	2e-13	287	556
STKc_PKB	cd05571	1.8e-11	287	557
STKc_SGK	cd05575	4.5e-08	287	558
STKc_aPKC	cd05588	1.5e-07	287	558
STKc_nPKC_eta	cd05590	8.8e-08	287	558
STKc_nPKC_epsilon	cd05591	1.5e-09	287	556
STKc_nPKC_theta_delt	cd05592	1.1e-08	287	557
STKc_PKB_gamma	cd05593	1.4e-09	287	559
STKc_PKB_alpha	cd05594	6.1e-11	287	558
STKc_PKB_beta	cd05595	1e-08	287	559
STKc_SGK1	cd05602	8.8e-08	287	558
STKc_SGK2	cd05603	1.7e-09	287	559
STKc_SGK3	cd05604	1.1e-05	287	558
STKc_aPKC_zeta	cd05617	3.8e-07	287	556
STKc_aPKC_iota	cd05618	3.1e-05	287	558
STKc_nPKC_theta	cd05619	2.1e-09	287	559
STKc_nPKC_delta	cd05620	1.2e-05	287	557
STKc_MEKK1_plant	cd06632	8.7e-47	287	534
PTKc_Zap-70	cd05115	2.4e-05	288	537
PK_STRAD_beta	cd08226	1.7e-06	288	549
PKc	cd00180	8.1e-86	289	532
STKc_AGC	cd05123	3e-31	289	534
STKc_GRK	cd05577	5.2e-11	289	550
STKc_cGK_PKG	cd05572	5.2e-15	289	535
STKc_YPK1_like	cd05585	1.5e-09	289	559
STKc_Sck1_like	cd05586	8.1e-06	289	559
STKc_MAST_like	cd05579	9.4e-21	289	535
STKc_beta_ARK	cd05606	4.8e-09	289	550
STKc_GRK1	cd05608	1.6e-10	289	550
STKc_GRK7	cd05607	6.5e-07	289	555
STKc_Rim15_like	cd05611	9.3e-08	289	540
STKc_GRK3	cd05633	8.7e-08	289	551
PBD	pfam00786	1e-21	69	142
Pkinase	pfam00069	8e-96	283	534
PBD	smart00285	4.1e-09	70	120
Pkinase_Tyr	pfam07714	1.2e-18	283	534
TyrKc	smart00219	7.1e-20	283	534
STYKc	smart00221	2.7e-89	283	534
S_TKc	smart00220	1.4e-96	293	534
KIND	smart00750	1.7e-77	363	542

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_023826	Disease	p.ALA380GLU	Mental retardation, X-linked 30 (MRX30)
Swiss-Prot	VAR_023825	Disease	p.ARG67CYS	Mental retardation, X-linked 30 (MRX30)
Swiss-Prot	VAR_046764	Polymorphism	p.THR440SER	N/A
OMIM	300142.0003	Disease	p.ALA344GLU	MENTAL RETARDATION, X-LINKED 30
OMIM	300142.0002	Disease	p.ARG67CYS	MENTAL RETARDATION, X-LINKED 30
OMIM	300142.0001	Disease	p.ARG398TER	MENTAL RETARDATION, X-LINKED 30
OMIM	300142.0004	Disease	p.TRP425SER	MENTAL RETARDATION, X-LINKED 30

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258