Results for the protein: O76039

Results for the Protein: O76039

6175070

6792

CDKL5

NCBI, UniProt

CDKL5_HUMAN RecName: Full=Cyclin-dependent kinase-like 5; AltName: Full=Serine/threonine-protein kinase 9

Known Diseases associated with this Protein:
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2 (EIEE2)

21

10

8

0

23

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

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Swiss-Prot Protein: O76039

Identical to: NP_001032420, NP_003150

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_FGFR1	cd05098	0.00019	1	270
PTKc_FGFR4	cd05099	8.7e-06	1	283
STKc_ROCK2	cd05621	1.6e-05	1	355
STKc_ROCK1	cd05622	0.00036	1	325
STKc_ROCK	cd05596	2.5e-05	1	357
STKc_TAO3	cd06633	5.9e-06	1	298
STKc_TAO1	cd06635	8e-08	1	298
STKc_MAP4K4_6	cd06636	7.2e-06	1	252
STKc_myosinIIIB	cd06639	1.1e-06	1	264
STKc_STK10_LOK	cd06644	6.4e-08	1	285
STKc_PAK_I	cd06647	2.2e-07	1	289
STKc_PAK2	cd06655	1.2e-07	1	295
STKc_PAK3	cd06656	1.2e-07	1	296
STKc_PAK6	cd06659	4.9e-08	1	291
STKc_PAK1	cd06654	1.7e-07	1	294
STKc_JNK	cd07850	3.6e-31	1	333
STKc_p38	cd07851	5.2e-25	1	340
STKc_CDK9	cd07865	1e-37	1	297
STKc_JNK1	cd07875	5.4e-12	1	350
STKc_p38delta_MAPK13	cd07879	1.4e-33	1	351
PTKc_FGFR2	cd05101	3.5e-05	2	270
STKc_PAK	cd06614	2.2e-17	2	306
PTKc_Tie2	cd05088	8.6e-05	3	267
STKc_myosinIIIA	cd06638	1.1e-06	3	271
STKc_PAK_II	cd06648	2.7e-09	3	274
STKc_PAK4	cd06657	5.7e-07	3	279
STKc_PAK5	cd06658	5.6e-07	3	288
STKc_Sty1_Hog1	cd07856	9e-24	3	318
PTKc_ALK_LTK	cd05036	0.00032	4	251
PTKc_FGFR3	cd05100	0.00048	4	300
STKc_TAO	cd06607	1.8e-07	4	337
STKc_TAO2	cd06634	1.6e-08	4	299
STKc_CDK10	cd07845	1.9e-55	4	307
PTKc_Hck	cd05073	3.7e-06	5	273
PKc_MKK7	cd06618	1.5e-09	5	276
STKc_ASK	cd06624	5e-08	5	263
STKc_JNK3	cd07874	1e-17	5	348
STKc_JNK2	cd07876	1.1e-15	5	348
STKc_p38alpha_MAPK14	cd07877	4.6e-23	5	337
STKc_p38gamma_MAPK12	cd07880	1.8e-28	5	339
STKc_p38beta_MAPK11	cd07878	7.1e-27	5	339
PTK_CCK4	cd05046	0.00046	6	253
PTKc_PDGFR	cd05055	5.1e-05	6	255
PTKc_FAK	cd05056	1.6e-06	6	270
STKc_myosinIII_like	cd06608	2.6e-10	6	252
STKc_TNIK	cd06637	4.1e-07	6	263
STKc_BUR1	cd07866	9.3e-42	6	297
STKc_PFTAIRE2	cd07870	1.9e-43	6	297
PTKc_Ror	cd05048	1.9e-05	7	258
STKc_SLK_like	cd06611	1.7e-09	7	305
STKc_SLK	cd06643	3.9e-08	7	313
STKc_CDC2L1	cd07843	9.7e-56	7	297
STKc_MAPK15	cd07852	1e-42	7	333
STKc_CDK12	cd07864	1.3e-53	7	297
PTKc_TrkB	cd05093	0.00024	8	272
PTKc_TrkA	cd05092	0.00054	8	264
STKc_MST4	cd06640	2.7e-07	8	278
STKc_MST3	cd06641	1.8e-07	8	298
STKc_STK25-YSK1	cd06642	3.1e-08	8	281
STKc_MAP4K3	cd06645	2.3e-08	8	262
STKc_MAP4K5	cd06646	1.1e-07	8	291
STKc_PCTAIRE_like	cd07844	1.2e-66	8	297
STKc_ERK1_2_like	cd07849	5.8e-38	8	344
STKc_MAPK4_6	cd07854	1.3e-15	8	340
STKc_ERK5	cd07855	2.5e-24	8	338
STKc_TEY_MAPK_plant	cd07858	1.7e-62	8	343
PTKc_InsR_like	cd05032	3.9e-05	9	260
PTKc_InsR	cd05061	0.00064	9	282
PTKc_Fyn_Yrk	cd05070	0.00029	9	273
PTKc_Lyn	cd05072	1.2e-05	9	273
STKc_MST1_2	cd06612	1.7e-14	9	297
PKc_MKK4	cd06616	2e-08	9	270
STKc_MAP4K3_like	cd06613	3.1e-13	9	256
STKc_YSK4	cd06631	9.2e-10	9	263
PTKc_EphR	cd05033	0.00018	10	307
PTKc_Csk_like	cd05039	3.4e-05	10	223
PTKc_Trk	cd05049	2.1e-07	10	249
PTKc_Abl	cd05052	2.4e-07	10	262
PTKc_Tec_like	cd05059	5e-06	10	271
PTKc_EphR_B	cd05065	5.2e-05	10	275
PTKc_EphR_A	cd05066	0.00032	10	274
PTKc_Frk_like	cd05068	3e-07	10	273
PTKc_Lck_Blk	cd05067	0.00026	10	273
PTKc_Csk	cd05082	9.6e-05	10	254
PTKc_Chk	cd05083	0.00013	10	261
PTKc_DDR2	cd05095	0.00087	10	259
PTKc_DDR_like	cd05097	0.0009	10	253
PTKc_Itk	cd05112	1.3e-06	10	257
PTKc_Btk_Bmx	cd05113	8e-07	10	252
PTKc_Tec_Rlk	cd05114	5.3e-06	10	253
STKc_PFTAIRE1	cd07869	3.6e-41	10	307
STKc_PCTAIRE3	cd07871	3.7e-52	10	297
STKc_PCTAIRE2	cd07872	4e-41	10	324
STKc_PCTAIRE1	cd07873	1.4e-48	10	307
STKc_Nek6_Nek7	cd08224	5e-11	10	275
STKc_Nek6	cd08228	2.2e-08	10	275
STKc_Nek7	cd08229	2.6e-10	10	264
PTKc_Src_like	cd05034	5.8e-06	11	273
PTKc_Musk	cd05050	5.3e-07	11	260
PTKc_FGFR	cd05053	1.3e-05	11	251
PTKc_EphR_A2	cd05063	0.00077	11	274
PTKc_Jak_rpt2	cd05038	1e-07	11	253
STKc_ROCK_NDR_like	cd05573	5.4e-13	11	367
STKc_PKA	cd05580	3.5e-13	11	346
STKc_phototropin_lik	cd05574	2.4e-05	11	262
STKc_PDK1	cd05581	1.8e-18	11	297
STKc_DMPK_like	cd05597	6.9e-09	11	322
STKc_LATS	cd05598	1.4e-06	11	366
STKc_NDR_like	cd05599	1.1e-07	11	278
STKc_Sid2p_Dbf2p	cd05600	5.5e-09	11	344
STKc_CRIK	cd05601	9.1e-10	11	367
STKc_MAST	cd05609	2.2e-09	11	324
STKc_PRKX_like	cd05612	9.9e-08	11	336
STKc_MRCK_alpha	cd05623	3.5e-08	11	301
STKc_LATS1	cd05625	2.6e-05	11	346
STKc_LATS2	cd05626	7.2e-05	11	343
STKc_NDR2	cd05627	8.3e-06	11	357
STKc_NDR1	cd05628	2.2e-06	11	334
STKc_NDR_like_fungal	cd05629	0.00055	11	357
STKc_MRCK_beta	cd05624	5e-08	11	300
PKc_MAPKK	cd06605	2.4e-12	11	260
STKc_MST3_like	cd06609	4.2e-11	11	266
STKc_OSR1_SPAK	cd06610	4.9e-11	11	297
PKc_MEK	cd06615	4.8e-12	11	323
PKc_MKK3_6	cd06617	5.7e-10	11	274
PKc_MAPKK_Byr1_like	cd06620	3.7e-07	11	322
PKc_MAPKK_Pek1_like	cd06621	1.3e-10	11	266
PKc_MAPKK_PBS2_like	cd06622	1.5e-08	11	314
STKc_MEKK1	cd06630	4.3e-09	11	298
PKc_MAPKK_plant_like	cd06623	2.9e-18	11	301
PKc_MEK1	cd06650	1.7e-06	11	352
STKc_MEKK2	cd06652	6.7e-06	11	265
STKc_MEKK3_like_1	cd06653	4.9e-07	11	264
PKc_MEK2	cd06649	1.4e-07	11	333
PKc_MKK5	cd06619	1.2e-05	11	315
STKc_NAK1_like	cd06917	5.8e-10	11	278
STKc_CDKL	cd07833	1.3e-221	11	297
STKc_CdkB_plant	cd07837	4.6e-66	11	298
STKc_CDKL1_4	cd07847	8.4e-116	11	297
STKc_CDKL5	cd07848	6.7e-251	11	297
STKc_CDKL2_3	cd07846	2.8e-131	11	297
STKc_CDK6	cd07862	6e-42	11	297
SPS1	COG0515	5.2e-67	11	483
PTKc_RET	cd05045	0.00054	12	241
PKc_STE	cd05122	2.4e-19	12	297
STKc_MSK_N	cd05583	5.1e-09	12	315
STKc_Yank1	cd05578	2.1e-12	12	297
STKc_cPKC	cd05587	2.7e-08	12	368
STKc_GRK4_like	cd05605	2.1e-09	12	301
STKc_MSK2_N	cd05614	2e-08	12	354
STKc_cPKC_alpha	cd05615	1.1e-07	12	325
STKc_cPKC_beta	cd05616	2.1e-06	12	335
STKc_GRK6	cd05630	1.4e-05	12	295
STKc_GRK4	cd05631	2.1e-06	12	295
STKc_GRK5	cd05632	7.3e-07	12	295
STKc_MSK1_N	cd05613	2.3e-08	12	315
STKc_MAPKKK	cd06606	1.2e-19	12	297
STKc_MAPKKK_Byr2_lik	cd06628	8.2e-12	12	266
STKc_Cdc7_like	cd06627	9.6e-16	12	297
STKc_MEKK3	cd06651	7.2e-09	12	265
STKc_CCRK	cd07832	6.1e-83	12	298
STKc_Pho85	cd07836	3.3e-71	12	297
STKc_MAPK	cd07834	1.5e-55	12	337
STKc_CDK5	cd07839	2.1e-71	12	297
STKc_CDK7	cd07841	2.9e-60	12	304
STKc_CDK8_like	cd07842	1.5e-34	12	297
STKc_NLK	cd07853	6e-18	12	366
STKc_TDY_MAPK_plant	cd07859	5e-56	12	339
STKc_CDK2_3	cd07860	7e-72	12	297
STKc_CDK1_euk	cd07861	9.9e-79	12	297
STKc_CDK4	cd07863	7.9e-44	12	297
STKc_MPK1	cd07857	3.2e-37	12	333
STKc_Nek1	cd08218	3.7e-19	12	263
STKc_Nek3	cd08219	4.2e-21	12	263
STKc_Nek2	cd08217	1.2e-17	12	297
STKc_Nek9	cd08221	1.4e-10	12	297
STKc_Nek11	cd08222	2.3e-07	12	271
STKc_Nek4	cd08223	6.1e-12	12	263
STKc_Nek5	cd08225	1.9e-18	12	263
STKc_Nek8	cd08220	2.9e-15	12	297
STKc_Nek	cd08215	4.3e-21	12	297
STKc_Nek10	cd08528	3e-09	12	246
STKc_FA2-like	cd08529	2.4e-13	12	252
STKc_CNK2-like	cd08530	8.5e-12	12	297
PTKc_Yes	cd05069	2.4e-05	13	262
PTKc_Src	cd05071	1.8e-05	13	264
PTKc_Jak1_rpt2	cd05079	6.4e-05	13	301
PTKc_Tyk2_rpt2	cd05080	1.7e-05	13	254
PTKc_Jak2_Jak3_rpt2	cd05081	1.4e-06	13	256
STKc_CMGC	cd05118	1.3e-121	13	297
PTKc_Srm_Brk	cd05148	2e-05	13	254
STKc_PKN	cd05589	9.9e-08	13	345
STKc_MAPKKK_Bck1_lik	cd06629	4.4e-07	13	257
STKc_CDK_like	cd07829	4.7e-102	13	297
STKc_MAK_like	cd07830	3.5e-74	13	297
STKc_CDK1_like	cd07835	5.6e-76	13	297
STKc_CDK4_6_like	cd07838	1.6e-38	13	297
STKc_CDK9_like	cd07840	2.4e-72	13	297
STKc_MOK	cd07831	7.4e-57	13	297
STKc_CDK8	cd07868	1.2e-13	13	297
STKc_CDC2L6	cd07867	1e-16	13	297
PK_STRAD	cd08216	1.2e-05	14	305
PK_STRAD_beta	cd08226	0.00099	14	308
STKc_RSK_N	cd05582	1.2e-06	16	323
STKc_p70S6K	cd05584	3.7e-09	16	336
STKc_Rim15_like	cd05611	7.9e-06	16	299
STKc_MEKK4	cd06626	3.2e-14	16	297
PTKc	cd00192	1.7e-10	17	296
PTKc_Ack_like	cd05040	3.3e-06	17	251
PTKc_c-ros	cd05044	0.00073	17	246
PTKc_Tie	cd05047	0.00065	17	264
PTKc_Met_Ron	cd05058	0.00032	17	276
PTKc_Syk_like	cd05060	0.00016	17	256
PTKc_Fes	cd05084	9.1e-06	17	260
PTKc_Fer	cd05085	3.7e-06	17	265
PTKc_Syk	cd05116	4.1e-06	17	264
STKc_PKC	cd05570	1.8e-09	17	287
STKc_PKB	cd05571	1.2e-09	17	334
STKc_SGK	cd05575	9.1e-07	17	322
STKc_aPKC	cd05588	1.8e-08	17	361
STKc_nPKC_eta	cd05590	7.8e-06	17	304
STKc_nPKC_theta_delt	cd05592	4.1e-08	17	331
STKc_PKB_gamma	cd05593	2.9e-06	17	327
STKc_PKB_beta	cd05595	6.7e-06	17	334
STKc_SGK1	cd05602	3.6e-06	17	354
STKc_PKB_alpha	cd05594	1.1e-06	17	326
STKc_SGK2	cd05603	1.4e-08	17	335
STKc_SGK3	cd05604	0.00014	17	336
STKc_aPKC_zeta	cd05617	2.9e-07	17	347
STKc_aPKC_iota	cd05618	7.2e-06	17	327
STKc_nPKC_theta	cd05619	4.3e-08	17	320
STKc_nPKC_delta	cd05620	9.4e-05	17	320
STKc_nPKC_epsilon	cd05591	1.7e-08	17	304
STKc_beta_ARK	cd05606	4e-06	18	283
STKc_GRK3	cd05633	7.9e-05	18	314
STKc_MEKK3_like	cd06625	6.6e-12	18	252
STKc_MEKK1_plant	cd06632	2.4e-11	18	252
PKc	cd00180	8.3e-79	19	295
PTKc_Fes_like	cd05041	9.3e-07	19	229
PTKc_Aatyk	cd05042	9.3e-06	19	254
PTKc_Zap-70	cd05115	6.6e-05	19	264
STKc_AGC	cd05123	3.1e-17	19	297
STKc_cGK_PKG	cd05572	5.5e-12	19	251
STKc_GRK	cd05577	2.7e-07	19	272
STKc_MAST_like	cd05579	2.6e-15	19	299
STKc_YPK1_like	cd05585	5.7e-10	19	355
STKc_Sck1_like	cd05586	3.4e-09	19	389
STKc_GRK7	cd05607	5e-07	19	300
STKc_GRK1	cd05608	7.4e-09	19	299
Pkinase	pfam00069	8.9e-96	13	297
Pkinase_Tyr	pfam07714	8.1e-14	13	249
TyrKc	smart00219	1e-12	13	258
STYKc	smart00221	3e-89	13	297
S_TKc	smart00220	2e-94	23	297

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041997	Polymorphism	p.ALA374THR	N/A
Swiss-Prot	VAR_058022	Disease	p.ALA40VAL	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_058031	Polymorphism	p.ARG444CYS	N/A
Swiss-Prot	VAR_058033	Polymorphism	p.ARG923CYS	N/A
Swiss-Prot	VAR_058026	Disease	p.ARG178PRO	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_023561	Disease	p.ARG175SER	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_036578	Polymorphism	p.ASN368HIS	N/A
Swiss-Prot	VAR_058030	Disease	p.ASN399THR	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_023560	Disease	p.CYS152PHE	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_058029	Disease	p.CYS291TYR	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_023562	Polymorphism	p.GLN791PRO	N/A
Swiss-Prot	VAR_042000	Polymorphism	p.GLU1023GLY	N/A
Swiss-Prot	VAR_058025	Disease	p.HIS127ARG	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_058023	Disease	p.ILE72ASN	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_058024	Disease	p.ILE72THR	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_058027	Disease	p.LEU220PRO	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_041998	Polymorphism	p.PRO574GLN	N/A
Swiss-Prot	VAR_037635	Disease	p.PRO180LEU	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_041999	Polymorphism	p.THR734ALA	N/A
Swiss-Prot	VAR_058028	Disease	p.THR288ILE	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_037636	Polymorphism	p.VAL793ALA	N/A
Swiss-Prot	VAR_058032	Disease	p.VAL718MET	Epileptic encephalopathy, early infantile, 2 (EIEE2)
Swiss-Prot	VAR_037637	Polymorphism	p.VAL999MET	N/A
OMIM	300203.0009	Disease	p.ALA40VAL	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2
OMIM	300203.0014	Disease	p.ARG178PRO	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2
OMIM	300203.0004	Disease	p.ARG175SER	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2
OMIM	300203.0003	Disease	p.CYS152PHE	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2
OMIM	300203.0012	Disease	p.CYS291TYR	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2
OMIM	300203.0007	Disease	p.GLN834TER	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2
OMIM	300203.0010	Disease	p.ILE72THR	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2
OMIM	300203.0011	Disease	p.THR288ILE	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258