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  Domain Name: Activin_recp
Activin types I and II receptor domain. This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.
No pairwise interactions found for the domain Activin_recp

Total Mutations Found: 11
Total Disease Mutations Found: 9
This domain occurred 10 times on human genes (17 proteins).



  HETEROTAXY, VISCERAL, 4, AUTOSOMAL
  JUVENILE POLYPOSIS SYNDROME
  MULTIPLE SELF-HEALING SQUAMOUS EPITHELIOMA, SUSCEPTIBILITY TO
  PULMONARY HYPERTENSION, PRIMARY, 1
  PULMONARY VENOOCCLUSIVE DISEASE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Activin_recp








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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