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  Domain Name: CT
C-terminal cystine knot-like domain (CTCK). The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.
No pairwise interactions found for the domain CT

Total Mutations Found: 28
Total Disease Mutations Found: 24
This domain occurred 23 times on human genes (47 proteins).



  ARTHROPATHY, PROGRESSIVE PSEUDORHEUMATOID, OF CHILDHOOD
  EXUDATIVE VITREORETINOPATHY 2, X-LINKED
  NORRIE DISEASE
  SCLEROSTEOSIS
  SPONDYLOEPIPHYSEAL DYSPLASIA TARDA WITH PROGRESSIVE ARTHROPATHY
  VON WILLEBRAND DISEASE, TYPE 2A


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for CT








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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