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  Domain Name: GH20_DspB_LnbB-like
Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)-N-acetylglucosamine), a major component of the extracellular polysaccharide matrix. Lacto-N-biosidase hydrolyzes lacto-N-biose (LNB) type I oligosaccharides at the nonreducing terminus to produce lacto-N-biose as part of the GNB/LNB (galacto-N-biose/lacto-N-biose I) degradation pathway. The lacto-N-biosidase from Bifidobacterium bifidum has this GH20 domain, a carbohydrate binding module 32, and a bacterial immunoglobulin-like domain 2, as well as a YSIRK signal peptide and a G5 membrane anchor at the N and C termini, respectively. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 38
Total Disease Mutations Found: 34
This domain occurred 3 times on human genes (4 proteins).



  BETA-HEXOSAMINIDASE A, PSEUDODEFICIENCY OF
  GM2-GANGLIOSIDOSIS, ADULT
  GM2-GANGLIOSIDOSIS, B1 VARIANT
  GM2-GANGLIOSIDOSIS, LATE ONSET
  GM2-GANGLIOSIDOSIS, SUBACUTE
  HEXA, CZECHOSLOVAKIAN ALLELE
  HEXA, DN ALLELE
  SANDHOFF DISEASE, ADULT TYPE
  SANDHOFF DISEASE, CHRONIC
  SANDHOFF DISEASE, INFANTILE
  SANDHOFF DISEASE, JUVENILE TYPE
  TAY-SACHS DISEASE
  TAY-SACHS DISEASE, B1 VARIANT
  TAY-SACHS DISEASE, JUVENILE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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